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001005762 1001_ $$00000-0001-5443-8540$$aKuzkina, Anastasia$$b0$$eFirst author
001005762 245__ $$aDermal Real‐Time Quaking‐Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α‐Synucleinopathy
001005762 260__ $$aNew York, NY$$bWiley$$c2023
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001005762 520__ $$aABSTRACT:Background:Skin biopsy is apotential tool for the premortem confirmation of anα-synucleinopathy.Objective:The aim was to assess the aggregationassay real-time quaking-induced conversion (RT-QuIC)of skin biopsy lysates to confirm isolated rapid eyemovement sleep behavior disorder (iRBD) as anα-synucleinopathy.Methods:Skin  biopsies  of  patients  with  iRBD,Parkinson’s disease (PD), and controls were analyzedusing RT-QuIC and immunohistochemical detection ofphospho-α-synuclein.Results:α-Synuclein aggregation was detected in97.4% of iRBD patients (78.4% of iRBD biopsies),87.2% of PD patients (70% of PD biopsies), and 13%of controls (7.9% of control biopsies), with a higherseeding activity in iRBD compared to PD. RT-QuICwas  more  sensitive  but  less  specific  thanimmunohistochemistry.Conclusions:Dermal RT-QuIC is a sensitive methodto detectα-synuclein aggregation in iRBD, and highseeding activity may indicate a strong involvement ofdermal nervefibers in these patients. © 2023 TheAuthors.Movement   Disorderspublished by WileyPeriodicals LLC on behalf of International Parkinsonand Movement Disorder Society.Key Words:rapid eye movement sleep behavior dis-order;α-synuclein;  Parkinson’s  disease;  real-timequaking-induced conversion; skin biopsy
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001005762 7001_ $$0P:(DE-Juel1)184882$$aSeger, Aline$$b2$$ufzj
001005762 7001_ $$0P:(DE-HGF)0$$aSchmitt, Daniela$$b3
001005762 7001_ $$0P:(DE-HGF)0$$aRößle, Jonas$$b4
001005762 7001_ $$0P:(DE-HGF)0$$aSchreglmann, Sebastian R.$$b5
001005762 7001_ $$0P:(DE-HGF)0$$aKnacke, Henrike$$b6
001005762 7001_ $$0P:(DE-HGF)0$$aSalabasidou, Elena$$b7
001005762 7001_ $$0P:(DE-HGF)0$$aKohl, Antonia$$b8
001005762 7001_ $$0P:(DE-HGF)0$$aSittig, Elisabeth$$b9
001005762 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael$$b10
001005762 7001_ $$0P:(DE-HGF)0$$aBerg, Daniela$$b11
001005762 7001_ $$0P:(DE-HGF)0$$aVolkmann, Jens$$b12
001005762 7001_ $$0P:(DE-HGF)0$$aSommer, Claudia$$b13
001005762 7001_ $$0P:(DE-HGF)0$$aOertel, Wolfgang H.$$b14
001005762 7001_ $$00000-0002-0792-4383$$aSchaeffer, Eva$$b15
001005762 7001_ $$0P:(DE-Juel1)179044$$aSommerauer, Michael$$b16
001005762 7001_ $$00000-0001-8907-5831$$aJanzen, Annette$$b17
001005762 7001_ $$00000-0003-2883-0009$$aDoppler, Kathrin$$b18$$eCorresponding author
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