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@ARTICLE{Kuzkina:1005762,
      author       = {Kuzkina, Anastasia and Panzer, Celine and Seger, Aline and
                      Schmitt, Daniela and Rößle, Jonas and Schreglmann,
                      Sebastian R. and Knacke, Henrike and Salabasidou, Elena and
                      Kohl, Antonia and Sittig, Elisabeth and Barbe, Michael and
                      Berg, Daniela and Volkmann, Jens and Sommer, Claudia and
                      Oertel, Wolfgang H. and Schaeffer, Eva and Sommerauer,
                      Michael and Janzen, Annette and Doppler, Kathrin},
      title        = {{D}ermal {R}eal‐{T}ime {Q}uaking‐{I}nduced {C}onversion
                      {I}s a {S}ensitive {M}arker to {C}onfirm {I}solated {R}apid
                      {E}ye {M}ovement {S}leep {B}ehavior {D}isorder as an {E}arly
                      α‐{S}ynucleinopathy},
      journal      = {Movement disorders},
      volume       = {38},
      number       = {6},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {FZJ-2023-01616},
      pages        = {mds.29340},
      year         = {2023},
      abstract     = {ABSTRACT:Background:Skin biopsy is apotential tool for the
                      premortem confirmation of anα-synucleinopathy.Objective:The
                      aim was to assess the aggregationassay real-time
                      quaking-induced conversion (RT-QuIC)of skin biopsy lysates
                      to confirm isolated rapid eyemovement sleep behavior
                      disorder (iRBD) as anα-synucleinopathy.Methods:Skin
                      biopsies of patients with iRBD,Parkinson’s disease (PD),
                      and controls were analyzedusing RT-QuIC and
                      immunohistochemical detection
                      ofphospho-α-synuclein.Results:α-Synuclein aggregation was
                      detected $in97.4\%$ of iRBD patients $(78.4\%$ of iRBD
                      $biopsies),87.2\%$ of PD patients $(70\%$ of PD biopsies),
                      and $13\%of$ controls $(7.9\%$ of control biopsies), with a
                      higherseeding activity in iRBD compared to PD. RT-QuICwas
                      more sensitive but less specific
                      thanimmunohistochemistry.Conclusions:Dermal RT-QuIC is a
                      sensitive methodto detectα-synuclein aggregation in iRBD,
                      and highseeding activity may indicate a strong involvement
                      ofdermal nervefibers in these patients. © 2023
                      TheAuthors.Movement Disorderspublished by WileyPeriodicals
                      LLC on behalf of International Parkinsonand Movement
                      Disorder Society.Key Words:rapid eye movement sleep behavior
                      dis-order;α-synuclein; Parkinson’s disease;
                      real-timequaking-induced conversion; skin biopsy},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / DFG
                      project 491111487 - Open-Access-Publikationskosten / 2022 -
                      2024 / Forschungszentrum Jülich (OAPKFZJ) (491111487)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(GEPRIS)491111487},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36750755},
      UT           = {WOS:000930736600001},
      doi          = {10.1002/mds.29340},
      url          = {https://juser.fz-juelich.de/record/1005762},
}