TY  - JOUR
AU  - Maleki Balajoo, Somayeh
AU  - Eickhoff, Simon B.
AU  - Masouleh, Shahrzad Kharabian
AU  - Plachti, Anna
AU  - Waite, Laura
AU  - Saberi, Amin
AU  - Bahri, Mohamed Ali
AU  - Bastin, Christine
AU  - Salmon, Eric
AU  - Hoffstaedter, Felix
AU  - Palomero-Gallagher, Nicola
AU  - Genon, Sarah
TI  - Hippocampal metabolic subregions and networks: Behavioral, molecular, and pathological aging profiles
JO  - Alzheimer's and dementia
VL  - 19
IS  - 11
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - FZJ-2023-01786
SP  - 4787-4804
PY  - 2023
AB  - INTRODUCTIONHippocampal local and network dysfunction is the hallmark of Alzheimer's disease (AD).METHODSWe characterized the spatial patterns of hippocampus differentiation based on brain co-metabolism in healthy elderly participants and demonstrated their relevance to study local metabolic changes and associated dysfunction in pathological aging.RESULTSThe hippocampus can be differentiated into anterior/posterior and dorsal cornu ammonis (CA)/ventral (subiculum) subregions. While anterior/posterior CA show co-metabolism with different regions of the subcortical limbic networks, the anterior/posterior subiculum are parts of cortical networks supporting object-centered memory and higher cognitive demands, respectively. Both networks show relationships with the spatial patterns of gene expression pertaining to cell energy metabolism and AD's process. Finally, while local metabolism is generally lower in posterior regions, the anterior–posterior imbalance is maximal in late mild cognitive impairment with the anterior subiculum being relatively preserved.DISCUSSIONFuture studies should consider bidimensional hippocampal differentiation and in particular the posterior subicular region to better understand pathological aging.
LB  - PUB:(DE-HGF)16
C6  - 37014937
UR  - <Go to ISI:>//WOS:000962826300001
DO  - DOI:10.1002/alz.13056
UR  - https://juser.fz-juelich.de/record/1006667
ER  -