Journal Article

FZJ-2023-01786

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Hippocampal metabolic subregions and networks: Behavioral, molecular, and pathological aging profiles

Maleki Balajoo, S. (Corresponding author)FZJ* ; Eickhoff, S. B.FZJ* ; Masouleh, S. K. ; Plachti, A. ; Waite, L.FZJ* ; Saberi, A.FZJ* ; Bahri, M. A. ; Bastin, C. ; Salmon, E. ; Hoffstaedter, F.FZJ* ; Palomero-Gallagher, N.FZJ* ; Genon, S.FZJ*

2023
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.13056  doi:10.34734/FZJ-2023-01786

Abstract: INTRODUCTIONHippocampal local and network dysfunction is the hallmark of Alzheimer's disease (AD).METHODSWe characterized the spatial patterns of hippocampus differentiation based on brain co-metabolism in healthy elderly participants and demonstrated their relevance to study local metabolic changes and associated dysfunction in pathological aging.RESULTSThe hippocampus can be differentiated into anterior/posterior and dorsal cornu ammonis (CA)/ventral (subiculum) subregions. While anterior/posterior CA show co-metabolism with different regions of the subcortical limbic networks, the anterior/posterior subiculum are parts of cortical networks supporting object-centered memory and higher cognitive demands, respectively. Both networks show relationships with the spatial patterns of gene expression pertaining to cell energy metabolism and AD's process. Finally, while local metabolism is generally lower in posterior regions, the anterior–posterior imbalance is maximal in late mild cognitive impairment with the anterior subiculum being relatively preserved.DISCUSSIONFuture studies should consider bidimensional hippocampal differentiation and in particular the posterior subicular region to better understand pathological aging.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)
2. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)
3. JL SMHB - Joint Lab Supercomputing and Modeling for the Human Brain (JL SMHB-2021-2027) (JL SMHB-2021-2027)
4. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
5. DFG project 491111487 - Open-Access-Publikationskosten / 2022 - 2024 / Forschungszentrum Jülich (OAPKFZJ) (491111487) (491111487)

Appears in the scientific report 2023

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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