TY  - JOUR
AU  - Plachti, Anna
AU  - Latzman, Robert D.
AU  - Balajoo, Somayeh Maleki
AU  - Hoffstaedter, Felix
AU  - Madsen, Kathrine Skak
AU  - Baare, William
AU  - Siebner, Hartwig R.
AU  - Eickhoff, Simon B.
AU  - Genon, Sarah
TI  - Hippocampal anterior- posterior shift in childhood and adolescence
JO  - Progress in neurobiology
VL  - 225
SN  - 0301-0082
CY  - Jena
PB  - Elsevier
M1  - FZJ-2023-01966
SP  - 102447 -
PY  - 2023
AB  - Hippocampal-cortical networks play an important role in neurocognitive development. Applying the method of Connectivity-Based Parcellation (CBP) on hippocampal-cortical structural covariance (SC) networks computed from T1-weighted magnetic resonance images, we examined how the hippocampus differentiates into subregions during childhood and adolescence (N = 1105, 6–18 years). In late childhood, the hippocampus mainly differentiated along the anterior-posterior axis similar to previous reported functional differentiation patterns of the hippocampus. In contrast, in adolescence a differentiation along the medial-lateral axis was evident, reminiscent of the cytoarchitectonic division into cornu ammonis and subiculum. Further meta-analytical characterization of hippocampal subregions in terms of related structural co-maturation networks, behavioural and gene profiling suggested that the hippocampal head is related to higher order functions (e.g. language, theory of mind, autobiographical memory) in late childhood morphologically co-varying with almost the whole brain. In early adolescence but not in childhood, posterior subicular SC networks were associated with action-oriented and reward systems. The findings point to late childhood as an important developmental period for hippocampal head morphology and to early adolescence as a crucial period for hippocampal integration into action- and reward-oriented cognition. The latter may constitute a developmental feature that conveys increased propensity for addictive disorders.
LB  - PUB:(DE-HGF)16
C6  - 36967075
UR  - <Go to ISI:>//WOS:000983085600001
DO  - DOI:10.1016/j.pneurobio.2023.102447
UR  - https://juser.fz-juelich.de/record/1007149
ER  -