Hippocampal anterior- posterior shift in childhood and adolescence

Plachti, Anna; Baare, William; Hoffstaedter, Felix; Eickhoff, Simon B.; Siebner, Hartwig R.; Balajoo, Somayeh Maleki; Madsen, Kathrine Skak; Latzman, Robert D.; Genon, Sarah

doi:10.1016/j.pneurobio.2023.102447

Journal Article

FZJ-2023-01966

Hippocampal anterior- posterior shift in childhood and adolescence

Plachti, A. ; Latzman, R. D. ; Balajoo, S. M. ; Hoffstaedter, F.FZJ* ; Madsen, K. S. ; Baare, W. ; Siebner, H. R. ; Eickhoff, S. B.FZJ* ; Genon, S. (Corresponding author)FZJ*

2023
Elsevier Jena

Progress in neurobiology 225, 102447 - (2023) [10.1016/j.pneurobio.2023.102447]

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Please use a persistent id in citations: http://hdl.handle.net/2128/34363 doi:10.1016/j.pneurobio.2023.102447 doi:10.34734/FZJ-2023-01966

Abstract: Hippocampal-cortical networks play an important role in neurocognitive development. Applying the method of Connectivity-Based Parcellation (CBP) on hippocampal-cortical structural covariance (SC) networks computed from T1-weighted magnetic resonance images, we examined how the hippocampus differentiates into subregions during childhood and adolescence (N = 1105, 6–18 years). In late childhood, the hippocampus mainly differentiated along the anterior-posterior axis similar to previous reported functional differentiation patterns of the hippocampus. In contrast, in adolescence a differentiation along the medial-lateral axis was evident, reminiscent of the cytoarchitectonic division into cornu ammonis and subiculum. Further meta-analytical characterization of hippocampal subregions in terms of related structural co-maturation networks, behavioural and gene profiling suggested that the hippocampal head is related to higher order functions (e.g. language, theory of mind, autobiographical memory) in late childhood morphologically co-varying with almost the whole brain. In early adolescence but not in childhood, posterior subicular SC networks were associated with action-oriented and reward systems. The findings point to late childhood as an important developmental period for hippocampal head morphology and to early adolescence as a crucial period for hippocampal integration into action- and reward-oriented cognition. The latter may constitute a developmental feature that conveys increased propensity for addictive disorders.

Classification:

ddc:610

Contributing Institute(s):

Gehirn & Verhalten (INM-7)

Research Program(s):

5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2023

Database coverage:
Medline

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