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@ARTICLE{Plachti:1007149,
author = {Plachti, Anna and Latzman, Robert D. and Balajoo, Somayeh
Maleki and Hoffstaedter, Felix and Madsen, Kathrine Skak and
Baare, William and Siebner, Hartwig R. and Eickhoff, Simon
B. and Genon, Sarah},
title = {{H}ippocampal anterior- posterior shift in childhood and
adolescence},
journal = {Progress in neurobiology},
volume = {225},
issn = {0301-0082},
address = {Jena},
publisher = {Elsevier},
reportid = {FZJ-2023-01966},
pages = {102447 -},
year = {2023},
abstract = {Hippocampal-cortical networks play an important role in
neurocognitive development. Applying the method of
Connectivity-Based Parcellation (CBP) on
hippocampal-cortical structural covariance (SC) networks
computed from T1-weighted magnetic resonance images, we
examined how the hippocampus differentiates into subregions
during childhood and adolescence (N = 1105, 6–18 years).
In late childhood, the hippocampus mainly differentiated
along the anterior-posterior axis similar to previous
reported functional differentiation patterns of the
hippocampus. In contrast, in adolescence a differentiation
along the medial-lateral axis was evident, reminiscent of
the cytoarchitectonic division into cornu ammonis and
subiculum. Further meta-analytical characterization of
hippocampal subregions in terms of related structural
co-maturation networks, behavioural and gene profiling
suggested that the hippocampal head is related to higher
order functions (e.g. language, theory of mind,
autobiographical memory) in late childhood morphologically
co-varying with almost the whole brain. In early adolescence
but not in childhood, posterior subicular SC networks were
associated with action-oriented and reward systems. The
findings point to late childhood as an important
developmental period for hippocampal head morphology and to
early adolescence as a crucial period for hippocampal
integration into action- and reward-oriented cognition. The
latter may constitute a developmental feature that conveys
increased propensity for addictive disorders.},
cin = {INM-7},
ddc = {610},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)16},
pubmed = {36967075},
UT = {WOS:000983085600001},
doi = {10.1016/j.pneurobio.2023.102447},
url = {https://juser.fz-juelich.de/record/1007149},
}