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000010078 0247_ $$2DOI$$a10.1093/hmg/ddq009
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000010078 084__ $$2WoS$$aBiochemistry & Molecular Biology
000010078 084__ $$2WoS$$aGenetics & Heredity
000010078 1001_ $$0P:(DE-HGF)0$$aIngason, A.$$b0
000010078 245__ $$aA large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia
000010078 260__ $$aOxford$$bOxford Univ. Press$$c2010
000010078 300__ $$a1379 - 1386
000010078 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000010078 440_0 $$09913$$aHuman Molecular Genetics$$v19$$x0964-6906$$y7
000010078 500__ $$aFunding for the project was provided by the Wellcome Trust under award 076113. Part of the genotyping of the Munich sample was done at the Genetics Research Centre (GmbH) which is a joint venture between GlaxoSmithKline Germany and the Department of Psychiatry, Ludwig-Maximilians-University. This work was funded by EU grants LSHM-CT-2006-037761 (Project SGENE) and PIAP-GA-2008-218251 (Project PsychGene). The Cardiff research was funded by grants from the MRC and the Wellcome Trust. The UCLA-Utrecht research was funded by NIH grant R01 MH078075.
000010078 520__ $$aThe Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7 x 10(-3), common OR = 1.09-1.11). The region contains two genes, AHI1 and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.
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000010078 536__ $$0G:(EU-Grant)218251$$aPSYCHGENE - Copy Number Variation and Endophenotypes in Psychiatric Disorders (218251)$$c218251$$fFP7-PEOPLE-2007-3-1-IAPP$$x2
000010078 588__ $$aDataset connected to Web of Science, Pubmed
000010078 650_2 $$2MeSH$$aAdaptor Proteins, Signal Transducing: genetics
000010078 650_2 $$2MeSH$$aEuropean Continental Ancestry Group: genetics
000010078 650_2 $$2MeSH$$aGenetic Markers
000010078 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000010078 650_2 $$2MeSH$$aGenome-Wide Association Study
000010078 650_2 $$2MeSH$$aHumans
000010078 650_2 $$2MeSH$$aSchizophrenia: genetics
000010078 650_7 $$00$$2NLM Chemicals$$aAHI1 protein, human
000010078 650_7 $$00$$2NLM Chemicals$$aAdaptor Proteins, Signal Transducing
000010078 650_7 $$00$$2NLM Chemicals$$aGenetic Markers
000010078 650_7 $$2WoSType$$aJ
000010078 7001_ $$0P:(DE-HGF)0$$aGiegling, I.$$b1
000010078 7001_ $$0P:(DE-Juel1)VDB92668$$aCichon, S.$$b2$$uFZJ
000010078 7001_ $$0P:(DE-HGF)0$$aHansen, T.$$b3
000010078 7001_ $$0P:(DE-HGF)0$$aRasmussen, H.B.$$b4
000010078 7001_ $$0P:(DE-HGF)0$$aNielsen, J.$$b5
000010078 7001_ $$0P:(DE-HGF)0$$aJürgens, G.$$b6
000010078 7001_ $$0P:(DE-HGF)0$$aMuglia, P.$$b7
000010078 7001_ $$0P:(DE-HGF)0$$aHartmann, A.M.$$b8
000010078 7001_ $$0P:(DE-HGF)0$$aStrengman, E.$$b9
000010078 7001_ $$0P:(DE-HGF)0$$aVasilescu, C.$$b10
000010078 7001_ $$0P:(DE-HGF)0$$aMühleisen, T.W.$$b11
000010078 7001_ $$0P:(DE-HGF)0$$aDjurovic, S.$$b12
000010078 7001_ $$0P:(DE-HGF)0$$aMelle, I.$$b13
000010078 7001_ $$0P:(DE-HGF)0$$aLerer, B.$$b14
000010078 7001_ $$0P:(DE-HGF)0$$aMöller, H.J.$$b15
000010078 7001_ $$0P:(DE-HGF)0$$aFrancks, C.$$b16
000010078 7001_ $$0P:(DE-HGF)0$$aPietiläinen, O.P.$$b17
000010078 7001_ $$0P:(DE-HGF)0$$aLonnqvist, J.$$b18
000010078 7001_ $$0P:(DE-HGF)0$$aSuvisaari, J.$$b19
000010078 7001_ $$0P:(DE-HGF)0$$aTuulio-Henriksson, A.$$b20
000010078 7001_ $$0P:(DE-HGF)0$$aWalshe, M.$$b21
000010078 7001_ $$0P:(DE-HGF)0$$aVassos, E.$$b22
000010078 7001_ $$0P:(DE-HGF)0$$aDi Forti, M.$$b23
000010078 7001_ $$0P:(DE-HGF)0$$aMurray, R.$$b24
000010078 7001_ $$0P:(DE-HGF)0$$aBonetto, C.$$b25
000010078 7001_ $$0P:(DE-HGF)0$$aTosato, S.$$b26
000010078 7001_ $$0P:(DE-HGF)0$$aGROUP, Investig.$$b27
000010078 7001_ $$0P:(DE-HGF)0$$aCantor, R.M.$$b28
000010078 7001_ $$0P:(DE-HGF)0$$aRietschel, M.$$b29
000010078 7001_ $$0P:(DE-HGF)0$$aCraddock, N.$$b30
000010078 7001_ $$0P:(DE-HGF)0$$aOwen, M.J.$$b31
000010078 7001_ $$0P:(DE-HGF)0$$aPeltonen, L.$$b32
000010078 7001_ $$0P:(DE-HGF)0$$aAndreassen, O.A.$$b33
000010078 7001_ $$0P:(DE-HGF)0$$aNöthen, M.M.$$b34
000010078 7001_ $$0P:(DE-HGF)0$$aSt. Clair, D.$$b35
000010078 7001_ $$0P:(DE-HGF)0$$aOphoff, R.A.$$b36
000010078 7001_ $$0P:(DE-HGF)0$$aO'Donovan, M.$$b37
000010078 7001_ $$0P:(DE-HGF)0$$aCollier, D.$$b38
000010078 7001_ $$0P:(DE-HGF)0$$aWerge, T.$$b39
000010078 7001_ $$0P:(DE-HGF)0$$aRujescu, D.$$b40
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