Journal Article

PreJuSER-10078

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

Ingason, A. ; Giegling, I. ; Cichon, S.FZJ* ; Hansen, T. ; Rasmussen, H. B. ; Nielsen, J. ; Jürgens, G. ; Muglia, P. ; Hartmann, A. M. ; Strengman, E. ; Vasilescu, C. ; Mühleisen, T. W. ; Djurovic, S. ; Melle, I. ; Lerer, B. ; Möller, H. J. ; Francks, C. ; Pietiläinen, O. P. ; Lonnqvist, J. ; Suvisaari, J. ; Tuulio-Henriksson, A. ; Walshe, M. ; Vassos, E. ; Di Forti, M. ; Murray, R. ; Bonetto, C. ; Tosato, S. ; GROUP, I. ; Cantor, R. M. ; Rietschel, M. ; Craddock, N. ; Owen, M. J. ; Peltonen, L. ; Andreassen, O. A. ; Nöthen, M. M. ; St. Clair, D. ; Ophoff, R. A. ; O'Donovan, M. ; Collier, D. ; Werge, T. ; Rujescu, D.

2010
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/hmg/ddq009

Abstract: The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7 x 10(-3), common OR = 1.09-1.11). The region contains two genes, AHI1 and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.

Keyword(s): Adaptor Proteins, Signal Transducing: genetics (MeSH) ; European Continental Ancestry Group: genetics (MeSH) ; Genetic Markers (MeSH) ; Genetic Predisposition to Disease (MeSH) ; Genome-Wide Association Study (MeSH) ; Humans (MeSH) ; Schizophrenia: genetics (MeSH) ; AHI1 protein, human ; Adaptor Proteins, Signal Transducing ; Genetic Markers ; J

Note: Funding for the project was provided by the Wellcome Trust under award 076113. Part of the genotyping of the Munich sample was done at the Genetics Research Centre (GmbH) which is a joint venture between GlaxoSmithKline Germany and the Department of Psychiatry, Ludwig-Maximilians-University. This work was funded by EU grants LSHM-CT-2006-037761 (Project SGENE) and PIAP-GA-2008-218251 (Project PsychGene). The Cardiff research was funded by grants from the MRC and the Wellcome Trust. The UCLA-Utrecht research was funded by NIH grant R01 MH078075.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. 89571 - Connectivity and Activity (POF2-89571) (POF2-89571)
3. PSYCHGENE - Copy Number Variation and Endophenotypes in Psychiatric Disorders (218251) (218251)

Appears in the scientific report 2010

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