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@ARTICLE{Ingason:10078,
      author       = {Ingason, A. and Giegling, I. and Cichon, S. and Hansen, T.
                      and Rasmussen, H.B. and Nielsen, J. and Jürgens, G. and
                      Muglia, P. and Hartmann, A.M. and Strengman, E. and
                      Vasilescu, C. and Mühleisen, T.W. and Djurovic, S. and
                      Melle, I. and Lerer, B. and Möller, H.J. and Francks, C.
                      and Pietiläinen, O.P. and Lonnqvist, J. and Suvisaari, J.
                      and Tuulio-Henriksson, A. and Walshe, M. and Vassos, E. and
                      Di Forti, M. and Murray, R. and Bonetto, C. and Tosato, S.
                      and GROUP, Investig. and Cantor, R.M. and Rietschel, M. and
                      Craddock, N. and Owen, M.J. and Peltonen, L. and Andreassen,
                      O.A. and Nöthen, M.M. and St. Clair, D. and Ophoff, R.A.
                      and O'Donovan, M. and Collier, D. and Werge, T. and Rujescu,
                      D.},
      title        = {{A} large replication study and meta-analysis in {E}uropean
                      samples provides further support for association of {AHI}1
                      markers with schizophrenia},
      journal      = {Human molecular genetics},
      volume       = {19},
      issn         = {0964-6906},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {PreJuSER-10078},
      pages        = {1379 - 1386},
      year         = {2010},
      note         = {Funding for the project was provided by the Wellcome Trust
                      under award 076113. Part of the genotyping of the Munich
                      sample was done at the Genetics Research Centre (GmbH) which
                      is a joint venture between GlaxoSmithKline Germany and the
                      Department of Psychiatry, Ludwig-Maximilians-University.
                      This work was funded by EU grants LSHM-CT-2006-037761
                      (Project SGENE) and PIAP-GA-2008-218251 (Project PsychGene).
                      The Cardiff research was funded by grants from the MRC and
                      the Wellcome Trust. The UCLA-Utrecht research was funded by
                      NIH grant R01 MH078075.},
      abstract     = {The Abelson helper integration site 1 (AHI1) gene locus on
                      chromosome 6q23 is among a group of candidate loci for
                      schizophrenia susceptibility that were initially identified
                      by linkage followed by linkage disequilibrium mapping, and
                      subsequent replication of the association in an independent
                      sample. Here, we present results of a replication study of
                      AHI1 locus markers, previously implicated in schizophrenia,
                      in a large European sample (in total 3907 affected and 7429
                      controls). Furthermore, we perform a meta-analysis of the
                      implicated markers in 4496 affected and 18,920 controls.
                      Both the replication study of new samples and the
                      meta-analysis show evidence for significant
                      overrepresentation of all tested alleles in patients
                      compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7
                      x 10(-3), common OR = 1.09-1.11). The region contains two
                      genes, AHI1 and C6orf217, and both genes-as well as the
                      neighbouring phosphodiesterase 7B (PDE7B)-may be considered
                      candidates for involvement in the genetic aetiology of
                      schizophrenia.},
      keywords     = {Adaptor Proteins, Signal Transducing: genetics / European
                      Continental Ancestry Group: genetics / Genetic Markers /
                      Genetic Predisposition to Disease / Genome-Wide Association
                      Study / Humans / Schizophrenia: genetics / AHI1 protein,
                      human (NLM Chemicals) / Adaptor Proteins, Signal Transducing
                      (NLM Chemicals) / Genetic Markers (NLM Chemicals) / J
                      (WoSType)},
      cin          = {INM-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571) / PSYCHGENE -
                      Copy Number Variation and Endophenotypes in Psychiatric
                      Disorders (218251)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571 /
                      G:(EU-Grant)218251},
      shelfmark    = {Biochemistry $\&$ Molecular Biology / Genetics $\&$
                      Heredity},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20071346},
      pmc          = {pmc:PMC2838541},
      UT           = {WOS:000275818500020},
      doi          = {10.1093/hmg/ddq009},
      url          = {https://juser.fz-juelich.de/record/10078},
}