%0 Electronic Article
%A Morales-Gregorio, Aitor
%A Kurth, Anno C.
%A Ito, Junji
%A Kleinjohann, Alexander
%A Barthélemy, Frédéric V.
%A Brochier, Thomas
%A Grün, Sonja
%A van Albada, Sacha J.
%T Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region
%I bioRxiv
%M FZJ-2023-02947
%D 2023
%X High-dimensional brain activity is often organised into lower-dimensional neural manifolds. However, the neural manifolds of the visual cortex remain understudied. Here, we study large-scale multielectrode electrophysiological recordings of macaque (Macaca mulatta) areas V1, V4 and DP with a high spatio-temporal resolution. We find, for the first time, that the population activity of V1 contains two separate neural manifolds, which correlate strongly with eye closure (eyes open/closed) and have distinct dimensionalities. Moreover, we find strong top-down signals from V4 to V1, particularly to the foveal region of V1, which are significantly stronger during the eyes-open periods, a previously unknown effect. Finally, in silico simulations of a balanced spiking neuron network qualitatively reproduce the experimental findings. Taken together, our analyses and simulations suggest that top-down signals modulate the population activity of V1, causing two distinct neural manifolds. We postulate that the top-down modulation during the eyes-open periods prepares V1 for fast and efficient visual responses, resulting in a type of visual stand-by mode.
%F PUB:(DE-HGF)25
%9 Preprint
%R 10.1101/2023.06.14.544966
%U https://juser.fz-juelich.de/record/1009715