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| Home > Publications database > Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region |
| Home > Publications database > Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region |
| Preprint | FZJ-2023-02947 |
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2023
bioRxiv
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Please use a persistent id in citations: doi:10.1101/2023.06.14.544966 doi:10.34734/FZJ-2023-02947
Abstract: High-dimensional brain activity is often organised into lower-dimensional neural manifolds. However, the neural manifolds of the visual cortex remain understudied. Here, we study large-scale multielectrode electrophysiological recordings of macaque (Macaca mulatta) areas V1, V4 and DP with a high spatio-temporal resolution. We find, for the first time, that the population activity of V1 contains two separate neural manifolds, which correlate strongly with eye closure (eyes open/closed) and have distinct dimensionalities. Moreover, we find strong top-down signals from V4 to V1, particularly to the foveal region of V1, which are significantly stronger during the eyes-open periods, a previously unknown effect. Finally, in silico simulations of a balanced spiking neuron network qualitatively reproduce the experimental findings. Taken together, our analyses and simulations suggest that top-down signals modulate the population activity of V1, causing two distinct neural manifolds. We postulate that the top-down modulation during the eyes-open periods prepares V1 for fast and efficient visual responses, resulting in a type of visual stand-by mode.
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