TY  - EJOUR
AU  - Morales-Gregorio, Aitor
AU  - Kurth, Anno C.
AU  - Ito, Junji
AU  - Kleinjohann, Alexander
AU  - Barthélemy, Frédéric V.
AU  - Brochier, Thomas
AU  - Grün, Sonja
AU  - van Albada, Sacha J.
TI  - Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region
PB  - bioRxiv
M1  - FZJ-2023-02947
PY  - 2023
AB  - High-dimensional brain activity is often organised into lower-dimensional neural manifolds. However, the neural manifolds of the visual cortex remain understudied. Here, we study large-scale multielectrode electrophysiological recordings of macaque (Macaca mulatta) areas V1, V4 and DP with a high spatio-temporal resolution. We find, for the first time, that the population activity of V1 contains two separate neural manifolds, which correlate strongly with eye closure (eyes open/closed) and have distinct dimensionalities. Moreover, we find strong top-down signals from V4 to V1, particularly to the foveal region of V1, which are significantly stronger during the eyes-open periods, a previously unknown effect. Finally, in silico simulations of a balanced spiking neuron network qualitatively reproduce the experimental findings. Taken together, our analyses and simulations suggest that top-down signals modulate the population activity of V1, causing two distinct neural manifolds. We postulate that the top-down modulation during the eyes-open periods prepares V1 for fast and efficient visual responses, resulting in a type of visual stand-by mode.
LB  - PUB:(DE-HGF)25
DO  - DOI:10.1101/2023.06.14.544966
UR  - https://juser.fz-juelich.de/record/1009715
ER  -