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| Hauptseite > Publikationsdatenbank > Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region > print |
| Hauptseite > Publikationsdatenbank > Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region > print |
| 001 | 1009715 | ||
| 005 | 20240313103110.0 | ||
| 024 | 7 | _ | |a 10.1101/2023.06.14.544966 |2 doi |
| 024 | 7 | _ | |a 10.34734/FZJ-2023-02947 |2 datacite_doi |
| 037 | _ | _ | |a FZJ-2023-02947 |
| 100 | 1 | _ | |a Morales-Gregorio, Aitor |0 P:(DE-Juel1)176593 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region |
| 260 | _ | _ | |c 2023 |b bioRxiv |
| 336 | 7 | _ | |a Preprint |b preprint |m preprint |0 PUB:(DE-HGF)25 |s 1695183420_22332 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Electronic Article |0 28 |2 EndNote |
| 336 | 7 | _ | |a preprint |2 DRIVER |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a Output Types/Working Paper |2 DataCite |
| 520 | _ | _ | |a High-dimensional brain activity is often organised into lower-dimensional neural manifolds. However, the neural manifolds of the visual cortex remain understudied. Here, we study large-scale multielectrode electrophysiological recordings of macaque (Macaca mulatta) areas V1, V4 and DP with a high spatio-temporal resolution. We find, for the first time, that the population activity of V1 contains two separate neural manifolds, which correlate strongly with eye closure (eyes open/closed) and have distinct dimensionalities. Moreover, we find strong top-down signals from V4 to V1, particularly to the foveal region of V1, which are significantly stronger during the eyes-open periods, a previously unknown effect. Finally, in silico simulations of a balanced spiking neuron network qualitatively reproduce the experimental findings. Taken together, our analyses and simulations suggest that top-down signals modulate the population activity of V1, causing two distinct neural manifolds. We postulate that the top-down modulation during the eyes-open periods prepares V1 for fast and efficient visual responses, resulting in a type of visual stand-by mode. |
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| 700 | 1 | _ | |a van Albada, Sacha J. |0 P:(DE-Juel1)138512 |b 7 |
| 773 | _ | _ | |a 10.1101/2023.06.14.544966 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1009715/files/2023.06.14.544966.full.pdf |y OpenAccess |
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