%0 Journal Article
%A Kasteel, R.
%A Mboh, C.M.
%A Unold, M.
%A Groeneweg, J.
%A Vanderborght, J.
%A Vereecken, H.
%T Transformation and sorption of the veterinary antibiotic sulfadiazine in two soils: A short-term batch study
%J Environmental Science & Technology
%V 44
%@ 0013-936X
%C Columbus, Ohio
%I American Chemical Society
%M PreJuSER-10169
%P 4651 - 4657
%D 2010
%Z C.M.M. and M.U. acknowledge the German Research Foundation (DFG) for financial support (FOR566). We thank Stephan Koppchen for the HPLC measurements and Bayer HealthCare (Wuppertal, Germany) for providing the <SUP>14</SUP>C-labeled sulfadiazine.
%X The worldwide use of veterinary antibiotics poses a continuous threat to the environment. There is, however, a lack of mechanistic studies on sorption and transformation processes for environmental assessment in soils. Two-week batch sorption experiments were performed with the antibiotic sulfadiazine (SDZ) in the plow layer and the subsoil of a loamy sand and a silty loam. The sorption and transformation parameters of SDZ and its main transformation products N1-2-(4-hydroxypyrimidinyl) benzenesulfanilamide (4-OH-SDZ) and 4-(2-iminopyrimidin-1(2H)-yl)aniline (An-SDZ) were estimated using a global optimization algorithm. A two-stage, one-rate sorption model combined with a first-order transformation model adequately described the batch data. Sorption of SDZ was nonlinear, time-dependent, and affected by pH, with a higher sorption capacity for the loamy sand. Transformation of SDZ into 4-OH-SDZ occurred only in the liquid phase, with half-life values of 1 month in the plow layers and 6 months in the subsoils. Under the exclusion of light, An-SDZ was formed in substantial amounts in the silty loam only, with liquid phase half-life values of 2 to 3 weeks. Despite the rather large parameter uncertainties, which may be reduced using additional information obtained from sequential solid phase extraction, the proposed method provides a framework to assess the fate of antibiotics in soils.
%K Adsorption
%K Biodegradation, Environmental
%K Biotransformation
%K Carbon Radioisotopes
%K Environmental Remediation: methods
%K Kinetics
%K Models, Chemical
%K Soil: analysis
%K Sulfadiazine: chemistry
%K Sulfadiazine: isolation & purification
%K Sulfadiazine: metabolism
%K Time Factors
%K Veterinary Drugs: chemistry
%K Veterinary Drugs: isolation & purification
%K Veterinary Drugs: metabolism
%K Carbon Radioisotopes (NLM Chemicals)
%K Soil (NLM Chemicals)
%K Veterinary Drugs (NLM Chemicals)
%K Sulfadiazine (NLM Chemicals)
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:20465301
%U <Go to ISI:>//WOS:000278617000045
%R 10.1021/es100141m
%U https://juser.fz-juelich.de/record/10169