Journal Article

PreJuSER-10169

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Transformation and sorption of the veterinary antibiotic sulfadiazine in two soils: A short-term batch study

Kasteel, R.FZJ* ; Mboh, C. M.FZJ* ; Unold, M.FZJ* ; Groeneweg, J.FZJ* ; Vanderborght, J.FZJ* ; Vereecken, H.FZJ*

2010
American Chemical Society Columbus, Ohio

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Please use a persistent id in citations: doi:10.1021/es100141m

Abstract: The worldwide use of veterinary antibiotics poses a continuous threat to the environment. There is, however, a lack of mechanistic studies on sorption and transformation processes for environmental assessment in soils. Two-week batch sorption experiments were performed with the antibiotic sulfadiazine (SDZ) in the plow layer and the subsoil of a loamy sand and a silty loam. The sorption and transformation parameters of SDZ and its main transformation products N1-2-(4-hydroxypyrimidinyl) benzenesulfanilamide (4-OH-SDZ) and 4-(2-iminopyrimidin-1(2H)-yl)aniline (An-SDZ) were estimated using a global optimization algorithm. A two-stage, one-rate sorption model combined with a first-order transformation model adequately described the batch data. Sorption of SDZ was nonlinear, time-dependent, and affected by pH, with a higher sorption capacity for the loamy sand. Transformation of SDZ into 4-OH-SDZ occurred only in the liquid phase, with half-life values of 1 month in the plow layers and 6 months in the subsoils. Under the exclusion of light, An-SDZ was formed in substantial amounts in the silty loam only, with liquid phase half-life values of 2 to 3 weeks. Despite the rather large parameter uncertainties, which may be reduced using additional information obtained from sequential solid phase extraction, the proposed method provides a framework to assess the fate of antibiotics in soils.

Keyword(s): Adsorption (MeSH) ; Biodegradation, Environmental (MeSH) ; Biotransformation (MeSH) ; Carbon Radioisotopes (MeSH) ; Environmental Remediation: methods (MeSH) ; Kinetics (MeSH) ; Models, Chemical (MeSH) ; Soil: analysis (MeSH) ; Sulfadiazine: chemistry (MeSH) ; Sulfadiazine: isolation & purification (MeSH) ; Sulfadiazine: metabolism (MeSH) ; Time Factors (MeSH) ; Veterinary Drugs: chemistry (MeSH) ; Veterinary Drugs: isolation & purification (MeSH) ; Veterinary Drugs: metabolism (MeSH) ; Carbon Radioisotopes ; Soil ; Veterinary Drugs ; Sulfadiazine ; J

Note: C.M.M. and M.U. acknowledge the German Research Foundation (DFG) for financial support (FOR566). We thank Stephan Koppchen for the HPLC measurements and Bayer HealthCare (Wuppertal, Germany) for providing the <SUP>14</SUP>C-labeled sulfadiazine.

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Research Program(s):

1. Terrestrische Umwelt (P24)

Appears in the scientific report 2010

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Database coverage:
; JCR ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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