TY  - JOUR
AU  - Kasteel, R.
AU  - Mboh, C.M.
AU  - Unold, M.
AU  - Groeneweg, J.
AU  - Vanderborght, J.
AU  - Vereecken, H.
TI  - Transformation and sorption of the veterinary antibiotic sulfadiazine in two soils: A short-term batch study
JO  - Environmental Science & Technology
VL  - 44
SN  - 0013-936X
CY  - Columbus, Ohio
PB  - American Chemical Society
M1  - PreJuSER-10169
SP  - 4651 - 4657
PY  - 2010
N1  - C.M.M. and M.U. acknowledge the German Research Foundation (DFG) for financial support (FOR566). We thank Stephan Koppchen for the HPLC measurements and Bayer HealthCare (Wuppertal, Germany) for providing the <SUP>14</SUP>C-labeled sulfadiazine.
AB  - The worldwide use of veterinary antibiotics poses a continuous threat to the environment. There is, however, a lack of mechanistic studies on sorption and transformation processes for environmental assessment in soils. Two-week batch sorption experiments were performed with the antibiotic sulfadiazine (SDZ) in the plow layer and the subsoil of a loamy sand and a silty loam. The sorption and transformation parameters of SDZ and its main transformation products N1-2-(4-hydroxypyrimidinyl) benzenesulfanilamide (4-OH-SDZ) and 4-(2-iminopyrimidin-1(2H)-yl)aniline (An-SDZ) were estimated using a global optimization algorithm. A two-stage, one-rate sorption model combined with a first-order transformation model adequately described the batch data. Sorption of SDZ was nonlinear, time-dependent, and affected by pH, with a higher sorption capacity for the loamy sand. Transformation of SDZ into 4-OH-SDZ occurred only in the liquid phase, with half-life values of 1 month in the plow layers and 6 months in the subsoils. Under the exclusion of light, An-SDZ was formed in substantial amounts in the silty loam only, with liquid phase half-life values of 2 to 3 weeks. Despite the rather large parameter uncertainties, which may be reduced using additional information obtained from sequential solid phase extraction, the proposed method provides a framework to assess the fate of antibiotics in soils.
KW  - Adsorption
KW  - Biodegradation, Environmental
KW  - Biotransformation
KW  - Carbon Radioisotopes
KW  - Environmental Remediation: methods
KW  - Kinetics
KW  - Models, Chemical
KW  - Soil: analysis
KW  - Sulfadiazine: chemistry
KW  - Sulfadiazine: isolation & purification
KW  - Sulfadiazine: metabolism
KW  - Time Factors
KW  - Veterinary Drugs: chemistry
KW  - Veterinary Drugs: isolation & purification
KW  - Veterinary Drugs: metabolism
KW  - Carbon Radioisotopes (NLM Chemicals)
KW  - Soil (NLM Chemicals)
KW  - Veterinary Drugs (NLM Chemicals)
KW  - Sulfadiazine (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:20465301
UR  - <Go to ISI:>//WOS:000278617000045
DO  - DOI:10.1021/es100141m
UR  - https://juser.fz-juelich.de/record/10169
ER  -