% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Glueck:1017087,
      author       = {Glueck, David and Grethen, Anne and Das, Manabendra and
                      Mmeka, Ogochukwu Patricia and Patallo, Eugenio Pérez and
                      Meister, Annette and Rajender, Ritu and Kins, Stefan and
                      Räschle, Markus and Victor, Julian and Chu, Ci and Etzkorn,
                      Manuel and Köck, Zoe and Bernhard, Frank and Babalola,
                      Jonathan Oyebamiji and Vargas, Carolyn and Keller, Sandro},
      title        = {{E}lectroneutral {P}olymer {N}anodiscs {E}nable
                      {I}nterference‐{F}ree {P}robing of {M}embrane {P}roteins
                      in a {L}ipid‐{B}ilayer {E}nvironment},
      journal      = {Small},
      volume       = {18},
      number       = {47},
      issn         = {1613-6810},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2023-03929},
      pages        = {2202492},
      year         = {2022},
      abstract     = {Membrane proteins can be examined in near-native
                      lipid-bilayer environments with the advent of
                      polymer-encapsulated nanodiscs. These nanodiscs
                      self-assemble directly from cellular membranes, allowing in
                      vitro probing of membrane proteins with techniques that have
                      previously been restricted to soluble or
                      detergent-solubilized proteins. Often, however, the high
                      charge densities of existing polymers obstruct bioanalytical
                      and preparative techniques. Thus, the authors aim to
                      fabricate electroneutral—yet water-soluble—polymer
                      nanodiscs. By attaching a sulfobetaine group to the
                      commercial polymers DIBMA and SMA(2:1), these polyanionic
                      polymers are converted to the electroneutral maleimide
                      derivatives, Sulfo-DIBMA and Sulfo-SMA(2:1). Sulfo-DIBMA and
                      Sulfo-SMA(2:1) readily extract proteins and phospholipids
                      from artificial and cellular membranes to form nanodiscs.
                      Crucially, the electroneutral nanodiscs avert unspecific
                      interactions, thereby enabling new insights into
                      protein–lipid interactions through lab-on-a-chip detection
                      and in vitro translation of membrane proteins. Finally, the
                      authors create a library comprising thousands of human
                      membrane proteins and use proteome profiling by mass
                      spectrometry to show that protein complexes are preserved in
                      electroneutral nanodiscs.},
      cin          = {IBI-7},
      ddc          = {620},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36228092},
      UT           = {WOS:000867936900001},
      doi          = {10.1002/smll.202202492},
      url          = {https://juser.fz-juelich.de/record/1017087},
}