%0 Journal Article
%A Linguiti, Sophia
%A Vogel, Jacob W.
%A Sydnor, Valerie J.
%A Pines, Adam
%A Wellman, Nick
%A Basbaum, Allan
%A Eickhoff, Claudia
%A Eickhoff, Simon B.
%A Edwards, Robert R.
%A Larsen, Bart
%A McKinstry-Wu, Andrew
%A Scott, J. Cobb
%A Roalf, David R.
%A Sharma, Vaishnavi
%A Strain, Eric C.
%A Corder, Gregory
%A Dworkin, Robert H.
%A Satterthwaite, Theodore D.
%T Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results
%J Neuroscience & biobehavioral reviews
%V 154
%@ 0149-7634
%C Amsterdam [u.a.]
%I Elsevier Science
%M FZJ-2023-04348
%P 105421 -
%D 2023
%X Functional magnetic resonance imaging (fMRI) is increasingly used to non-invasively study the acute impact of psychedelics on the human brain. While fMRI is a promising tool for measuring brain function in response to psychedelics, it also has known methodological challenges. We conducted a systematic review of fMRI studies examining acute responses to experimentally administered psychedelics in order to identify convergent findings and characterize heterogeneity in the literature. We reviewed 91 full-text papers; these studies were notable for substantial heterogeneity in design, task, dosage, drug timing, and statistical approach. Data recycling was common, with 51 unique samples across 91 studies. Fifty-seven studies (54%) did not meet contemporary standards for Type I error correction or control of motion artifact. Psilocybin and LSD were consistently reported to moderate the connectivity architecture of the sensorimotor-association cortical axis. Studies also consistently reported that ketamine administration increased activation in the dorsomedial prefrontal cortex. Moving forward, use of best practices such as pre-registration, standardized image processing and statistical testing, and data sharing will be important in this rapidly developing field.
%F PUB:(DE-HGF)36 ; PUB:(DE-HGF)16
%9 ReviewJournal Article
%$ 37802267
%U <Go to ISI:>//WOS:001099598200001
%R 10.1016/j.neubiorev.2023.105421
%U https://juser.fz-juelich.de/record/1017815