Review/Journal Article

FZJ-2023-04348

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results

Linguiti, S. ; Vogel, J. W. ; Sydnor, V. J. ; Pines, A. ; Wellman, N. ; Basbaum, A. ; Eickhoff, C. ; Eickhoff, S. B.FZJ* ; Edwards, R. R. ; Larsen, B. ; McKinstry-Wu, A. ; Scott, J. C. ; Roalf, D. R. ; Sharma, V. ; Strain, E. C. ; Corder, G. ; Dworkin, R. H. ; Satterthwaite, T. D. (Corresponding author)

2023
Elsevier Science Amsterdam [u.a.]

This record in other databases:      

Please use a persistent id in citations: doi:10.1016/j.neubiorev.2023.105421

Abstract: Functional magnetic resonance imaging (fMRI) is increasingly used to non-invasively study the acute impact of psychedelics on the human brain. While fMRI is a promising tool for measuring brain function in response to psychedelics, it also has known methodological challenges. We conducted a systematic review of fMRI studies examining acute responses to experimentally administered psychedelics in order to identify convergent findings and characterize heterogeneity in the literature. We reviewed 91 full-text papers; these studies were notable for substantial heterogeneity in design, task, dosage, drug timing, and statistical approach. Data recycling was common, with 51 unique samples across 91 studies. Fifty-seven studies (54%) did not meet contemporary standards for Type I error correction or control of motion artifact. Psilocybin and LSD were consistently reported to moderate the connectivity architecture of the sensorimotor-association cortical axis. Studies also consistently reported that ketamine administration increased activation in the dorsomedial prefrontal cortex. Moving forward, use of best practices such as pre-registration, standardized image processing and statistical testing, and data sharing will be important in this rapidly developing field.

---

Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)
2. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2023

---

Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---