TY  - JOUR
AU  - Linguiti, Sophia
AU  - Vogel, Jacob W.
AU  - Sydnor, Valerie J.
AU  - Pines, Adam
AU  - Wellman, Nick
AU  - Basbaum, Allan
AU  - Eickhoff, Claudia
AU  - Eickhoff, Simon B.
AU  - Edwards, Robert R.
AU  - Larsen, Bart
AU  - McKinstry-Wu, Andrew
AU  - Scott, J. Cobb
AU  - Roalf, David R.
AU  - Sharma, Vaishnavi
AU  - Strain, Eric C.
AU  - Corder, Gregory
AU  - Dworkin, Robert H.
AU  - Satterthwaite, Theodore D.
TI  - Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results
JO  - Neuroscience & biobehavioral reviews
VL  - 154
SN  - 0149-7634
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2023-04348
SP  - 105421 -
PY  - 2023
AB  - Functional magnetic resonance imaging (fMRI) is increasingly used to non-invasively study the acute impact of psychedelics on the human brain. While fMRI is a promising tool for measuring brain function in response to psychedelics, it also has known methodological challenges. We conducted a systematic review of fMRI studies examining acute responses to experimentally administered psychedelics in order to identify convergent findings and characterize heterogeneity in the literature. We reviewed 91 full-text papers; these studies were notable for substantial heterogeneity in design, task, dosage, drug timing, and statistical approach. Data recycling was common, with 51 unique samples across 91 studies. Fifty-seven studies (54%) did not meet contemporary standards for Type I error correction or control of motion artifact. Psilocybin and LSD were consistently reported to moderate the connectivity architecture of the sensorimotor-association cortical axis. Studies also consistently reported that ketamine administration increased activation in the dorsomedial prefrontal cortex. Moving forward, use of best practices such as pre-registration, standardized image processing and statistical testing, and data sharing will be important in this rapidly developing field.
LB  - PUB:(DE-HGF)36 ; PUB:(DE-HGF)16
C6  - 37802267
UR  - <Go to ISI:>//WOS:001099598200001
DO  - DOI:10.1016/j.neubiorev.2023.105421
UR  - https://juser.fz-juelich.de/record/1017815
ER  -