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@INPROCEEDINGS{Eivazi:1019318,
      author       = {Eivazi, Faranak and Krause, Hans-Joachim},
      title        = {{B}iomarker detection using {F}requency {M}ixing {M}agnetic
                      {D}etection {T}echnique},
      reportid     = {FZJ-2023-05292},
      year         = {2023},
      abstract     = {The electrolyte-insulator-semiconductor sensor (EIS)
                      provides a promising technique for the electrical detection
                      of biomarkers by their intrinsic electrical charge. Due to
                      the charge-screening effect, EIS sensors are less sensitive
                      when samples contain multiple charged species. Our study
                      combines the EIS sensor with the frequency mixing magnetic
                      detection (FMMD) technique to improve functionality and
                      produce more reliable results. The principle of the
                      dual-modality technique is to use superparamagnetic
                      nanoparticles (SPNs) as receptor carriers and pull them
                      towards the surface of the EIS with an external magnet. FMMD
                      exposes SPNs to both low-frequency and high-frequency
                      magnetic fields. The magnetic response of SPNs induces a
                      voltage in the detection coil. The hydrodynamic radius of
                      SPNs can be determined by observing a phase shift toward
                      lower frequencies caused by the Brownian relaxation of the
                      particles. The target can be confirmed when both techniques
                      detect it in a sample. As a result of this dual-modality
                      technique, selectivity and sensitivity can be highly
                      improved.},
      month         = {Mar},
      date          = {2023-03-26},
      organization  = {DPG-Frühjahrstagung, Sektion
                       Kondensierte Materie, Dresden
                       (Germany), 26 Mar 2023 - 31 Mar 2023},
      subtyp        = {Other},
      cin          = {IBI-3},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524) / DFG project 445454801 - Kombinierter
                      Feldeffekt-/Magnet-Immunsensor-Chip für den
                      markierungsfreien Nachweise von Biomarkern (FEMIC)
                      (445454801)},
      pid          = {G:(DE-HGF)POF4-5241 / G:(GEPRIS)445454801},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/1019318},
}