001019322 001__ 1019322
001019322 005__ 20231213202053.0
001019322 037__ $$aFZJ-2023-05296
001019322 041__ $$aEnglish
001019322 1001_ $$0P:(DE-HGF)0$$aSüß, Johanna$$b0$$eCorresponding author
001019322 1112_ $$a4th European BioSensor Symposium 2023$$cAachen$$d2023-08-27 - 2023-08-30$$gEBS 2023$$wGermany
001019322 245__ $$aHighly Crystalline Iron Oxide Nanoparticles for Nonlinear Magnetic Detection Methods Synthesized by Oxidative Aging
001019322 260__ $$c2023
001019322 3367_ $$033$$2EndNote$$aConference Paper
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001019322 520__ $$aIn the field of medical diagnostics and therapy, iron oxide nanoparticles (IONPs) offer auspicious possibilities. For utilization of IONPs as tracer material for magnetic particle imaging (MPI), for hyperthermia treatment or for nonlinear magnetic detection, particle sizes between 15-30 nm and a high crystallinity are required. In this context, we present oxidative aging as synthesis method to achieve crystalline magnetite nanoparticles with a narrow size distribution and a biocompatible coating. The synthesis by oxidative aging comprises precipitation of ferrous hydroxide and subsequent oxidation by KNO3 to octahedral magnetite crystals. The dependence of IONP size on the iron precursor concentration was investigated. With increasing iron concentration, increasing size was observed. The synthesized IONPs were coated with different biocompatible ligands such as dextran or dopamine to stabilize them in aqueous solution. The synthesized IONPs were characterized by dynamic light scattering, infrared spectroscopy, frequency mixing magnetic detection (FMMD), and scanning electron microscopy (SEM). Highly crystalline magnetite nanoparticles with sizes suitable for nonlinear magnetic detection methods like MPI or FMMD were synthesized by oxidative aging. The NPs are equipped with a biocompatible coating which is an excellent prerequisite for biomedical applications.
001019322 536__ $$0G:(DE-HGF)POF4-5241$$a5241 - Molecular Information Processing in Cellular Systems (POF4-524)$$cPOF4-524$$fPOF IV$$x0
001019322 536__ $$0G:(GEPRIS)445454801$$aDFG project 445454801 - Kombinierter Feldeffekt-/Magnet-Immunsensor-Chip für den markierungsfreien Nachweise von Biomarkern (FEMIC) (445454801)$$c445454801$$x1
001019322 7001_ $$0P:(DE-HGF)0$$aGüntner, Kilian$$b1
001019322 7001_ $$0P:(DE-Juel1)173858$$aPourshahidi, Ali Mohammad$$b2$$ufzj
001019322 7001_ $$0P:(DE-Juel1)128697$$aKrause, Hans-Joachim$$b3$$ufzj
001019322 7001_ $$0P:(DE-HGF)0$$aKaulen, Corinna$$b4
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001019322 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)173858$$aForschungszentrum Jülich$$b2$$kFZJ
001019322 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)128697$$aForschungszentrum Jülich$$b3$$kFZJ
001019322 9131_ $$0G:(DE-HGF)POF4-524$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5241$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vMolecular and Cellular Information Processing$$x0
001019322 9141_ $$y2023
001019322 920__ $$lyes
001019322 9201_ $$0I:(DE-Juel1)IBI-3-20200312$$kIBI-3$$lBioelektronik$$x0
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