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| Home > Publications database > Highly Crystalline Iron Oxide Nanoparticles for Nonlinear Magnetic Detection Methods Synthesized by Oxidative Aging |
| Home > Publications database > Highly Crystalline Iron Oxide Nanoparticles for Nonlinear Magnetic Detection Methods Synthesized by Oxidative Aging |
| Poster (Other) | FZJ-2023-05296 |
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2023
Abstract: In the field of medical diagnostics and therapy, iron oxide nanoparticles (IONPs) offer auspicious possibilities. For utilization of IONPs as tracer material for magnetic particle imaging (MPI), for hyperthermia treatment or for nonlinear magnetic detection, particle sizes between 15-30 nm and a high crystallinity are required. In this context, we present oxidative aging as synthesis method to achieve crystalline magnetite nanoparticles with a narrow size distribution and a biocompatible coating. The synthesis by oxidative aging comprises precipitation of ferrous hydroxide and subsequent oxidation by KNO3 to octahedral magnetite crystals. The dependence of IONP size on the iron precursor concentration was investigated. With increasing iron concentration, increasing size was observed. The synthesized IONPs were coated with different biocompatible ligands such as dextran or dopamine to stabilize them in aqueous solution. The synthesized IONPs were characterized by dynamic light scattering, infrared spectroscopy, frequency mixing magnetic detection (FMMD), and scanning electron microscopy (SEM). Highly crystalline magnetite nanoparticles with sizes suitable for nonlinear magnetic detection methods like MPI or FMMD were synthesized by oxidative aging. The NPs are equipped with a biocompatible coating which is an excellent prerequisite for biomedical applications.
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