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@INPROCEEDINGS{S:1019322,
      author       = {Süß, Johanna and Güntner, Kilian and Pourshahidi, Ali
                      Mohammad and Krause, Hans-Joachim and Kaulen, Corinna},
      title        = {{H}ighly {C}rystalline {I}ron {O}xide {N}anoparticles for
                      {N}onlinear {M}agnetic {D}etection {M}ethods {S}ynthesized
                      by {O}xidative {A}ging},
      reportid     = {FZJ-2023-05296},
      year         = {2023},
      abstract     = {In the field of medical diagnostics and therapy, iron oxide
                      nanoparticles (IONPs) offer auspicious possibilities. For
                      utilization of IONPs as tracer material for magnetic
                      particle imaging (MPI), for hyperthermia treatment or for
                      nonlinear magnetic detection, particle sizes between 15-30
                      nm and a high crystallinity are required. In this context,
                      we present oxidative aging as synthesis method to achieve
                      crystalline magnetite nanoparticles with a narrow size
                      distribution and a biocompatible coating. The synthesis by
                      oxidative aging comprises precipitation of ferrous hydroxide
                      and subsequent oxidation by KNO3 to octahedral magnetite
                      crystals. The dependence of IONP size on the iron precursor
                      concentration was investigated. With increasing iron
                      concentration, increasing size was observed. The synthesized
                      IONPs were coated with different biocompatible ligands such
                      as dextran or dopamine to stabilize them in aqueous
                      solution. The synthesized IONPs were characterized by
                      dynamic light scattering, infrared spectroscopy, frequency
                      mixing magnetic detection (FMMD), and scanning electron
                      microscopy (SEM). Highly crystalline magnetite nanoparticles
                      with sizes suitable for nonlinear magnetic detection methods
                      like MPI or FMMD were synthesized by oxidative aging. The
                      NPs are equipped with a biocompatible coating which is an
                      excellent prerequisite for biomedical applications.},
      month         = {Aug},
      date          = {2023-08-27},
      organization  = {4th European BioSensor Symposium 2023,
                       Aachen (Germany), 27 Aug 2023 - 30 Aug
                       2023},
      subtyp        = {Other},
      cin          = {IBI-3},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524) / DFG project 445454801 - Kombinierter
                      Feldeffekt-/Magnet-Immunsensor-Chip für den
                      markierungsfreien Nachweise von Biomarkern (FEMIC)
                      (445454801)},
      pid          = {G:(DE-HGF)POF4-5241 / G:(GEPRIS)445454801},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/1019322},
}