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001019834 005__ 20240226075524.0
001019834 0247_ $$2datacite_doi$$a10.34734/FZJ-2023-05665
001019834 0247_ $$2URN$$aurn:nbn:de:0001-20240124092709594-7519671-4
001019834 020__ $$a978-3-95806-726-4
001019834 037__ $$aFZJ-2023-05665
001019834 1001_ $$0P:(DE-Juel1)178720$$aSchwanemann, Tobias$$b0$$eCorresponding author$$ufzj
001019834 245__ $$aStrain- and process engineering for polyketides production with Pseudomonas taiwanensis VLB120 in two-phase cultivations$$f2020-02-01 - 2023-10-26
001019834 260__ $$aJülich$$bForschungszentrum Jülich GmbH Zentralbibliothek, Verlag$$c2023
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001019834 4900_ $$aSchriften des Forschungszentrums Jülich Reihe Schlüsseltechnologien / Key Technologies$$v276
001019834 502__ $$aDissertation, Univ. Düsseldorf, 2023$$bDissertation$$cUniv. Düsseldorf$$d2023
001019834 520__ $$aPolyketides are a highly diverse group of secondary metabolites with great potential for lead compounds for applications in multiple industries. Biotechnological hosts are frequently used for their heterologous production. For polyketide synthesis, identical precursors are assembled to complex compounds with highly different properties while using the same cellular resources. Consequently, the choice of polyketide synthase (PKS) determines the final product and the interchangeable nature of PKS allows the production of various compounds by minimal modifications of the host organism. In particular, PKS III represent an interesting group of catalysts due to their simplicity compared to other PKS. In this work, an alternative bacterial production host, Pseudomonas taiwanensis VLB120, was developed for the production of various polyketide products in two-phase cultivations for in situ product removal.
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