Book/Dissertation / PhD Thesis

FZJ-2023-05665

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Strain- and process engineering for polyketides production with Pseudomonas taiwanensis VLB120 in two-phase cultivations

Schwanemann, T. (Corresponding author)FZJ*

2023
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag Jülich
ISBN: 978-3-95806-726-4

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Please use a persistent id in citations: urn:nbn:de:0001-20240124092709594-7519671-4  doi:10.34734/FZJ-2023-05665

Abstract: Polyketides are a highly diverse group of secondary metabolites with great potential for lead compounds for applications in multiple industries. Biotechnological hosts are frequently used for their heterologous production. For polyketide synthesis, identical precursors are assembled to complex compounds with highly different properties while using the same cellular resources. Consequently, the choice of polyketide synthase (PKS) determines the final product and the interchangeable nature of PKS allows the production of various compounds by minimal modifications of the host organism. In particular, PKS III represent an interesting group of catalysts due to their simplicity compared to other PKS. In this work, an alternative bacterial production host, Pseudomonas taiwanensis VLB120, was developed for the production of various polyketide products in two-phase cultivations for in situ product removal.

Note: Dissertation, Univ. Düsseldorf, 2023

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Contributing Institute(s):

1. Biotechnologie (IBG-1)

Research Program(s):

1. 2172 - Utilization of renewable carbon and energy sources and engineering of ecosystem functions (POF4-217) (POF4-217)

Appears in the scientific report 2023

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Database coverage:
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