TY  - THES
AU  - Schwanemann, Tobias
TI  - Strain- and process engineering for polyketides production with Pseudomonas taiwanensis VLB120 in two-phase cultivations
VL  - 276
PB  - Univ. Düsseldorf
VL  - Dissertation
CY  - Jülich
M1  - FZJ-2023-05665
SN  - 978-3-95806-726-4
T2  - Schriften des Forschungszentrums Jülich Reihe Schlüsseltechnologien / Key Technologies
SP  - 230
PY  - 2023
N1  - Dissertation, Univ. Düsseldorf, 2023
AB  - Polyketides are a highly diverse group of secondary metabolites with great potential for lead compounds for applications in multiple industries. Biotechnological hosts are frequently used for their heterologous production. For polyketide synthesis, identical precursors are assembled to complex compounds with highly different properties while using the same cellular resources. Consequently, the choice of polyketide synthase (PKS) determines the final product and the interchangeable nature of PKS allows the production of various compounds by minimal modifications of the host organism. In particular, PKS III represent an interesting group of catalysts due to their simplicity compared to other PKS. In this work, an alternative bacterial production host, Pseudomonas taiwanensis VLB120, was developed for the production of various polyketide products in two-phase cultivations for in situ product removal.
LB  - PUB:(DE-HGF)3 ; PUB:(DE-HGF)11
DO  - DOI:10.34734/FZJ-2023-05665
UR  - https://juser.fz-juelich.de/record/1019834
ER  -