%0 Journal Article
%A Albus, Alexandra
%A Kronimus, Yannick
%A Burg-Roderfeld, Monika
%A van der Wurp, Hendrik
%A Willbold, Dieter
%A Ziehm, Tamar
%A Dodel, Richard
%A Ross, Jean Alexander
%T The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson’s Disease
%J Biomolecules
%V 13
%N 9
%@ 2218-273X
%C Basel
%I MDPI
%M FZJ-2024-00732
%P 1303 -
%D 2023
%X The accumulation and aggregation of alpha-synuclein (α-Syn) are pathological processes associated with Parkinson's disease, indicating that the regulation of protein is a crucial etiopathological mechanism. Interestingly, human serum and cerebrospinal fluid contain autoantibodies that recognize α-Syn. This potentially demonstrates an already existing, naturally decomposing, and protective system. Thus, quantitative or qualitative alterations, such as the modified antigen binding of so-called naturally occurring autoantibodies against α-Syn (nAbs-α-Syn), may induce disease onset and/or progression. We investigated the serum titers and binding characteristics of nAbs-α-Syn in patients suffering from sporadic Parkinson's disease (n = 38), LRRK2 mutation carriers (n = 25), and healthy controls (n = 22).
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 37759704
%U <Go to ISI:>//WOS:001074350200001
%R 10.3390/biom13091303
%U https://juser.fz-juelich.de/record/1021436