Journal Article

FZJ-2024-00732

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson’s Disease

Albus, A. ; Kronimus, Y. ; Burg-Roderfeld, M. ; van der Wurp, H. ; Willbold, D.FZJ* ; Ziehm, T. ; Dodel, R. (Corresponding author) ; Ross, J. A.

2023
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/biom13091303  doi:10.34734/FZJ-2024-00732

Abstract: The accumulation and aggregation of alpha-synuclein (α-Syn) are pathological processes associated with Parkinson's disease, indicating that the regulation of protein is a crucial etiopathological mechanism. Interestingly, human serum and cerebrospinal fluid contain autoantibodies that recognize α-Syn. This potentially demonstrates an already existing, naturally decomposing, and protective system. Thus, quantitative or qualitative alterations, such as the modified antigen binding of so-called naturally occurring autoantibodies against α-Syn (nAbs-α-Syn), may induce disease onset and/or progression. We investigated the serum titers and binding characteristics of nAbs-α-Syn in patients suffering from sporadic Parkinson's disease (n = 38), LRRK2 mutation carriers (n = 25), and healthy controls (n = 22).

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Contributing Institute(s):

1. Strukturbiochemie (IBI-7)

Research Program(s):

1. 5244 - Information Processing in Neuronal Networks (POF4-524) (POF4-524)

Appears in the scientific report 2023

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