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001021436 1001_ $$00000-0002-4897-6972$$aAlbus, Alexandra$$b0
001021436 245__ $$aThe Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson’s Disease
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001021436 520__ $$aThe accumulation and aggregation of alpha-synuclein (α-Syn) are pathological processes associated with Parkinson's disease, indicating that the regulation of protein is a crucial etiopathological mechanism. Interestingly, human serum and cerebrospinal fluid contain autoantibodies that recognize α-Syn. This potentially demonstrates an already existing, naturally decomposing, and protective system. Thus, quantitative or qualitative alterations, such as the modified antigen binding of so-called naturally occurring autoantibodies against α-Syn (nAbs-α-Syn), may induce disease onset and/or progression. We investigated the serum titers and binding characteristics of nAbs-α-Syn in patients suffering from sporadic Parkinson's disease (n = 38), LRRK2 mutation carriers (n = 25), and healthy controls (n = 22).
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001021436 7001_ $$0P:(DE-HGF)0$$aKronimus, Yannick$$b1
001021436 7001_ $$0P:(DE-HGF)0$$aBurg-Roderfeld, Monika$$b2
001021436 7001_ $$0P:(DE-HGF)0$$avan der Wurp, Hendrik$$b3
001021436 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b4
001021436 7001_ $$0P:(DE-Juel1)162487$$aZiehm, Tamar$$b5
001021436 7001_ $$0P:(DE-HGF)0$$aDodel, Richard$$b6$$eCorresponding author
001021436 7001_ $$00000-0001-9286-2748$$aRoss, Jean Alexander$$b7
001021436 773__ $$0PERI:(DE-600)2701262-1$$a10.3390/biom13091303$$gVol. 13, no. 9, p. 1303 -$$n9$$p1303 -$$tBiomolecules$$v13$$x2218-273X$$y2023
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