TY  - JOUR
AU  - Albus, Alexandra
AU  - Kronimus, Yannick
AU  - Burg-Roderfeld, Monika
AU  - van der Wurp, Hendrik
AU  - Willbold, Dieter
AU  - Ziehm, Tamar
AU  - Dodel, Richard
AU  - Ross, Jean Alexander
TI  - The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson’s Disease
JO  - Biomolecules
VL  - 13
IS  - 9
SN  - 2218-273X
CY  - Basel
PB  - MDPI
M1  - FZJ-2024-00732
SP  - 1303 -
PY  - 2023
AB  - The accumulation and aggregation of alpha-synuclein (α-Syn) are pathological processes associated with Parkinson's disease, indicating that the regulation of protein is a crucial etiopathological mechanism. Interestingly, human serum and cerebrospinal fluid contain autoantibodies that recognize α-Syn. This potentially demonstrates an already existing, naturally decomposing, and protective system. Thus, quantitative or qualitative alterations, such as the modified antigen binding of so-called naturally occurring autoantibodies against α-Syn (nAbs-α-Syn), may induce disease onset and/or progression. We investigated the serum titers and binding characteristics of nAbs-α-Syn in patients suffering from sporadic Parkinson's disease (n = 38), LRRK2 mutation carriers (n = 25), and healthy controls (n = 22).
LB  - PUB:(DE-HGF)16
C6  - 37759704
UR  - <Go to ISI:>//WOS:001074350200001
DO  - DOI:10.3390/biom13091303
UR  - https://juser.fz-juelich.de/record/1021436
ER  -