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@ARTICLE{Albus:1021436,
      author       = {Albus, Alexandra and Kronimus, Yannick and Burg-Roderfeld,
                      Monika and van der Wurp, Hendrik and Willbold, Dieter and
                      Ziehm, Tamar and Dodel, Richard and Ross, Jean Alexander},
      title        = {{T}he {A}vidity of {A}utoreactive {A}lpha-{S}ynuclein
                      {A}ntibodies in {L}eucine-{R}ich {R}epeat {K}inase 2
                      {M}utation {C}arriers {I}s {N}ot {A}ltered {C}ompared to
                      {H}ealthy {C}ontrols or {P}atients with {P}arkinson’s
                      {D}isease},
      journal      = {Biomolecules},
      volume       = {13},
      number       = {9},
      issn         = {2218-273X},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2024-00732},
      pages        = {1303 -},
      year         = {2023},
      abstract     = {The accumulation and aggregation of alpha-synuclein
                      (α-Syn) are pathological processes associated with
                      Parkinson's disease, indicating that the regulation of
                      protein is a crucial etiopathological mechanism.
                      Interestingly, human serum and cerebrospinal fluid contain
                      autoantibodies that recognize α-Syn. This potentially
                      demonstrates an already existing, naturally decomposing, and
                      protective system. Thus, quantitative or qualitative
                      alterations, such as the modified antigen binding of
                      so-called naturally occurring autoantibodies against α-Syn
                      (nAbs-α-Syn), may induce disease onset and/or progression.
                      We investigated the serum titers and binding characteristics
                      of nAbs-α-Syn in patients suffering from sporadic
                      Parkinson's disease (n = 38), LRRK2 mutation carriers (n =
                      25), and healthy controls (n = 22).},
      cin          = {IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37759704},
      UT           = {WOS:001074350200001},
      doi          = {10.3390/biom13091303},
      url          = {https://juser.fz-juelich.de/record/1021436},
}