Home > Publications database > The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson’s Disease > print

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100 1 _ |a Albus, Alexandra
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245 _ _ |a The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson’s Disease
260 _ _ |a Basel
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520 _ _ |a The accumulation and aggregation of alpha-synuclein (α-Syn) are pathological processes associated with Parkinson's disease, indicating that the regulation of protein is a crucial etiopathological mechanism. Interestingly, human serum and cerebrospinal fluid contain autoantibodies that recognize α-Syn. This potentially demonstrates an already existing, naturally decomposing, and protective system. Thus, quantitative or qualitative alterations, such as the modified antigen binding of so-called naturally occurring autoantibodies against α-Syn (nAbs-α-Syn), may induce disease onset and/or progression. We investigated the serum titers and binding characteristics of nAbs-α-Syn in patients suffering from sporadic Parkinson's disease (n = 38), LRRK2 mutation carriers (n = 25), and healthy controls (n = 22).
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700 1 _ |a Kronimus, Yannick
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700 1 _ |a Burg-Roderfeld, Monika
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700 1 _ |a van der Wurp, Hendrik
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700 1 _ |a Willbold, Dieter
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700 1 _ |a Ziehm, Tamar
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700 1 _ |a Dodel, Richard
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700 1 _ |a Ross, Jean Alexander
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773 _ _ |a 10.3390/biom13091303
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