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001022279 1001_ $$0P:(DE-HGF)0$$aKalc, Polona$$b0$$eCorresponding author
001022279 245__ $$aLow bone mineral density is associated with gray matter volume decrease in UK Biobank
001022279 260__ $$aLausanne$$bFrontiers Research Foundation$$c2023
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001022279 520__ $$aObjectives: Previous research has found an association of low bone mineral density (BMD) and regional gray matter (GM) volume loss in Alzheimer's disease (AD). We were interested whether BMD is associated with GM volume decrease in brains of a healthy elderly population from the UK Biobank.Materials and methods: T1-weighted images from 5,518 women (MAge = 70.20, SD = 3.54; age range: 65-82 years) and 7,595 men (MAge = 70.84, SD = 3.68; age range: 65-82 years) without neurological or psychiatric impairments were included in voxel-based morphometry (VBM) analysis in CAT12 with threshold-free-cluster-enhancement (TFCE) across the whole brain.Results: We found a significant decrease of GM volume in women in the superior frontal gyri, middle temporal gyri, fusiform gyri, temporal poles, cingulate gyri, precunei, right parahippocampal gyrus and right hippocampus, right ventral diencephalon, and right pre- and postcentral gyrus. Only small effects were found in men in subcallosal area, left basal forebrain and entorhinal area.Conclusion: BMD is associated with low GM volume in women but less in men in regions afflicted in the early-stages of AD even in a sample without neurodegenerative diseases.Keywords: Alzheimer’s disease; UK Biobank; VBM; bone mineral density; osteoporosis.
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001022279 7001_ $$aDahnke, Robert$$b1
001022279 7001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, Felix$$b2$$ufzj
001022279 7001_ $$aGaser, Christian$$b3
001022279 773__ $$0PERI:(DE-600)2558898-9$$a10.3389/fnagi.2023.1287304$$gVol. 15, p. 1287304$$p1287304$$tFrontiers in aging neuroscience$$v15$$x1663-4365$$y2023
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