Journal Article

FZJ-2024-01397

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Low bone mineral density is associated with gray matter volume decrease in UK Biobank

Kalc, P. (Corresponding author) ; Dahnke, R. ; Hoffstaedter, F.FZJ* ; Gaser, C.

2023
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: doi:10.3389/fnagi.2023.1287304  doi:10.34734/FZJ-2024-01397

Abstract: Objectives: Previous research has found an association of low bone mineral density (BMD) and regional gray matter (GM) volume loss in Alzheimer's disease (AD). We were interested whether BMD is associated with GM volume decrease in brains of a healthy elderly population from the UK Biobank.Materials and methods: T1-weighted images from 5,518 women (MAge = 70.20, SD = 3.54; age range: 65-82 years) and 7,595 men (MAge = 70.84, SD = 3.68; age range: 65-82 years) without neurological or psychiatric impairments were included in voxel-based morphometry (VBM) analysis in CAT12 with threshold-free-cluster-enhancement (TFCE) across the whole brain.Results: We found a significant decrease of GM volume in women in the superior frontal gyri, middle temporal gyri, fusiform gyri, temporal poles, cingulate gyri, precunei, right parahippocampal gyrus and right hippocampus, right ventral diencephalon, and right pre- and postcentral gyrus. Only small effects were found in men in subcallosal area, left basal forebrain and entorhinal area.Conclusion: BMD is associated with low GM volume in women but less in men in regions afflicted in the early-stages of AD even in a sample without neurodegenerative diseases.Keywords: Alzheimer’s disease; UK Biobank; VBM; bone mineral density; osteoporosis.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2023

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