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@ARTICLE{Kalc:1022279,
      author       = {Kalc, Polona and Dahnke, Robert and Hoffstaedter, Felix and
                      Gaser, Christian},
      title        = {{L}ow bone mineral density is associated with gray matter
                      volume decrease in {UK} {B}iobank},
      journal      = {Frontiers in aging neuroscience},
      volume       = {15},
      issn         = {1663-4365},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2024-01397},
      pages        = {1287304},
      year         = {2023},
      abstract     = {Objectives: Previous research has found an association of
                      low bone mineral density (BMD) and regional gray matter (GM)
                      volume loss in Alzheimer's disease (AD). We were interested
                      whether BMD is associated with GM volume decrease in brains
                      of a healthy elderly population from the UK
                      Biobank.Materials and methods: T1-weighted images from 5,518
                      women (MAge = 70.20, SD = 3.54; age range: 65-82 years) and
                      7,595 men (MAge = 70.84, SD = 3.68; age range: 65-82 years)
                      without neurological or psychiatric impairments were
                      included in voxel-based morphometry (VBM) analysis in CAT12
                      with threshold-free-cluster-enhancement (TFCE) across the
                      whole brain.Results: We found a significant decrease of GM
                      volume in women in the superior frontal gyri, middle
                      temporal gyri, fusiform gyri, temporal poles, cingulate
                      gyri, precunei, right parahippocampal gyrus and right
                      hippocampus, right ventral diencephalon, and right pre- and
                      postcentral gyrus. Only small effects were found in men in
                      subcallosal area, left basal forebrain and entorhinal
                      area.Conclusion: BMD is associated with low GM volume in
                      women but less in men in regions afflicted in the
                      early-stages of AD even in a sample without
                      neurodegenerative diseases.Keywords: Alzheimer’s disease;
                      UK Biobank; VBM; bone mineral density; osteoporosis.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38020770},
      UT           = {WOS:001104232800001},
      doi          = {10.3389/fnagi.2023.1287304},
      url          = {https://juser.fz-juelich.de/record/1022279},
}