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| Home > Publications database > Linking brain structure and genetic risk in large-scale data: A comparison of shared versus predominantly disorder-specific genetic risk for neuropsychiatric disorders |
| Contribution to a conference proceedings | FZJ-2024-02538 |
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2024
Elsevier Science
Amsterdam [u.a.]
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Please use a persistent id in citations: doi:10.1016/j.clinph.2023.12.074
Abstract: Shared and predominantly disorder-specific common genetic risk variants for neuropsychiatric disorders have been identified in previous studies. In particular, a large-scale genome-wide association study meta-analysis across eight neuropsychiatric disorders reported 23 highly pleiotropic single-nucleotide polymorphisms (SNPs) that are associated with at least four disorders as well as 22 SNPs that were predominantly associated with schizophrenia (SCZ) risk. Yet, their influences on brain structure which might be relevant for the increased vulnerability to multiple or specific neuropsychiatric disorders is not fully understood. In this study, we investigated and compared the cumulative influences of highly pleiotropic and predominantly SCZ-specific SNPs at the level of brain structure in the general population. Comparing their brain structural associations might point to brain regions of high transdiagnostic value as well as brain regions relevant to SCZ-specific risk pathways.
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