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| Home > Publications database > Comparison of histological delineation of the entorhinal, perirhinal, ectorhinal, and parahippocampal cortices by different neuroanatomy laboratories |
| Home > Publications database > Comparison of histological delineation of the entorhinal, perirhinal, ectorhinal, and parahippocampal cortices by different neuroanatomy laboratories |
| Abstract | FZJ-2024-02698 |
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2023
Abstract: The medial temporal lobe (MTL) cortex, located adjacent to the hippocampus,is crucial for memory and a hotspot of neurodegenerative processes (e.g.,accumulation of tau tangles or TDP-43). Importantly, theMTLcortex comprises severalsubregions with distinct functional, cytoarchitectonic, and macro-anatomical features(Fig. 1). In vivo imaging studies measuring atrophy or aggregates of pathologies in thesesubregions rely on various segmentation protocols. Comparability of these imagingstudies is limited as segmentation protocols differ, which results from different macroanatomicalparcellations and cytoarchitectonic definitions of MTL subregions. Thus,it must be clarified to which extent definitions of MTL subregions overlap betweenneuroanatomists, to establish a harmonized MTL magnetic resonance imaging (MRI)segmentation protocol. We give an overview of cytoarchitectonic definitions of MTLcortex subregions provided by four neuroanatomists from independent laboratories.
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