TY  - JOUR
AU  - Giehl, Kathrin
AU  - Theis, Hendrik
AU  - Ophey, Anja
AU  - Hammes, Jochen
AU  - Reker, Paul
AU  - Eggers, Carsten
AU  - Fink, Gereon R.
AU  - Kalbe, Elke
AU  - van Eimeren, Thilo
TI  - Working Memory Training Responsiveness in Parkinson’s Disease Is Not Determined by Cortical Thickness or White Matter Lesions
JO  - Journal of Parkinson's Disease
VL  - 14
IS  - 2
SN  - 1877-7171
CY  - Amsterdam
PB  - IOS Press
M1  - FZJ-2024-03151
SP  - 347 - 351
PY  - 2024
AB  - Patients with Parkinson's disease are highly vulnerable for cognitive decline. Thus, early intervention by means of working memory training (WMT) may be effective for the preservation of cognition. However, the influence of structural brain properties, i.e., cortical thickness and volume of white matter lesions on training responsiveness have not been studied. Here, behavioral and neuroimaging data of 46 patients with Parkinson's disease, 21 of whom engaged in home-based, computerized adaptive WMT, was analyzed. While cortical thickness and white matter lesions volume were associated with cognitive performance at baseline, these structural brain properties do not seem to determine WMT responsiveness.Keywords: MRI; Parkinson’s disease; Working memory training; cognition; cortical thickness; white matter lesion.
LB  - PUB:(DE-HGF)16
C6  - 38277302
UR  - <Go to ISI:>//WOS:001206999100011
DO  - DOI:10.3233/JPD-230367
UR  - https://juser.fz-juelich.de/record/1025788
ER  -