Journal Article

FZJ-2024-03151

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Working Memory Training Responsiveness in Parkinson’s Disease Is Not Determined by Cortical Thickness or White Matter Lesions

Giehl, K.FZJ* ; Theis, H. ; Ophey, A. ; Hammes, J. ; Reker, P. ; Eggers, C. ; Fink, G. R.FZJ* ; Kalbe, E. ; van Eimeren, T. (Corresponding author)

2024
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.3233/JPD-230367  doi:10.34734/FZJ-2024-03151

Abstract: Patients with Parkinson's disease are highly vulnerable for cognitive decline. Thus, early intervention by means of working memory training (WMT) may be effective for the preservation of cognition. However, the influence of structural brain properties, i.e., cortical thickness and volume of white matter lesions on training responsiveness have not been studied. Here, behavioral and neuroimaging data of 46 patients with Parkinson's disease, 21 of whom engaged in home-based, computerized adaptive WMT, was analyzed. While cortical thickness and white matter lesions volume were associated with cognitive performance at baseline, these structural brain properties do not seem to determine WMT responsiveness.Keywords: MRI; Parkinson’s disease; Working memory training; cognition; cortical thickness; white matter lesion.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)
2. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)
2. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2024

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