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@ARTICLE{Giehl:1025788,
      author       = {Giehl, Kathrin and Theis, Hendrik and Ophey, Anja and
                      Hammes, Jochen and Reker, Paul and Eggers, Carsten and Fink,
                      Gereon R. and Kalbe, Elke and van Eimeren, Thilo},
      title        = {{W}orking {M}emory {T}raining {R}esponsiveness in
                      {P}arkinson’s {D}isease {I}s {N}ot {D}etermined by
                      {C}ortical {T}hickness or {W}hite {M}atter {L}esions},
      journal      = {Journal of Parkinson's Disease},
      volume       = {14},
      number       = {2},
      issn         = {1877-7171},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {FZJ-2024-03151},
      pages        = {347 - 351},
      year         = {2024},
      abstract     = {Patients with Parkinson's disease are highly vulnerable for
                      cognitive decline. Thus, early intervention by means of
                      working memory training (WMT) may be effective for the
                      preservation of cognition. However, the influence of
                      structural brain properties, i.e., cortical thickness and
                      volume of white matter lesions on training responsiveness
                      have not been studied. Here, behavioral and neuroimaging
                      data of 46 patients with Parkinson's disease, 21 of whom
                      engaged in home-based, computerized adaptive WMT, was
                      analyzed. While cortical thickness and white matter lesions
                      volume were associated with cognitive performance at
                      baseline, these structural brain properties do not seem to
                      determine WMT responsiveness.Keywords: MRI; Parkinson’s
                      disease; Working memory training; cognition; cortical
                      thickness; white matter lesion.},
      cin          = {INM-2 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5253 -
                      Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38277302},
      UT           = {WOS:001206999100011},
      doi          = {10.3233/JPD-230367},
      url          = {https://juser.fz-juelich.de/record/1025788},
}