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@ARTICLE{EriaOliveira:1025966,
      author       = {Eria-Oliveira, Ana-Sofia and Folacci, Mathilde and Chassot,
                      Anne Amandine and Fedou, Sandrine and Thézé, Nadine and
                      Zabelskii, Dmitrii and Alekseev, Alexey and Bamberg, Ernst
                      and Gordeliy, Valentin and Sandoz, Guillaume and Vivaudou,
                      Michel},
      title        = {{H}ijacking of internal calcium dynamics by intracellularly
                      residing viral rhodopsins},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2024-03244},
      pages        = {65},
      year         = {2024},
      abstract     = {Rhodopsins are ubiquitous light-driven membrane proteins
                      with diverse functions, including ion transport. Widely
                      distributed, they are also coded in the genomes of giant
                      viruses infecting phytoplankton where their function is not
                      settled. Here, we examine the properties of OLPVR1 (Organic
                      Lake Phycodnavirus Rhodopsin) and two other type 1 viral
                      channelrhodopsins (VCR1s), and demonstrate that VCR1s
                      accumulate exclusively intracellularly, and, upon
                      illumination, induce calcium release from intracellular
                      IP3-dependent stores. In vivo, this light-induced calcium
                      release is sufficient to remote control muscle contraction
                      in VCR1-expressing tadpoles. VCR1s natively confer
                      light-induced Ca2+ release, suggesting a distinct mechanism
                      for reshaping the response to light of virus-infected algae.
                      The ability of VCR1s to photorelease calcium without
                      altering plasma membrane electrical properties marks them as
                      potential precursors for optogenetics tools, with potential
                      applications in basic research and medicine.},
      cin          = {IBI-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38167346},
      UT           = {WOS:001288614600035},
      doi          = {10.1038/s41467-023-44548-6},
      url          = {https://juser.fz-juelich.de/record/1025966},
}