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001028964 245__ $$aProgressive Supranuclear Palsy: Subcortical Tau Depositions Are Associated with Cortical Perfusion in Frontal and Limbic Regions
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001028964 520__ $$aIn progressive supranuclear palsy (PSP), subcortical tau and cortical perfusion can be assessed using the tracer [18F]PI-2620. We investigated if subcortical tau (globus pallidus internus, dentate nucleus) and frontal/limbic perfusion correlate in a cohort of 32 PSP patients. Tau in subcortical regions showed significant negative correlation with perfusion in limbic cortex. Perfusion in frontal regions was negatively associated with tau in both subcortical regions, but the significance threshold was only passed for the dentate nucleus. A reason could be a diaschisis-like phenomenon; that is, subcortical tau could lead to reduced connectivity to frontal regions and, thereby, to decreased perfusion.Keywords: FDG; PET; PSP; [18F]PI-2620; diaschisis; imaging; perfusion; progressive supranuclear palsy; tau.
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001028964 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael T.$$b1
001028964 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b2$$ufzj
001028964 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b3$$ufzj
001028964 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b4$$ufzj
001028964 7001_ $$0P:(DE-Juel1)166265$$aBischof, Gérard N.$$b5$$ufzj
001028964 7001_ $$0P:(DE-Juel1)169110$$avan Eimeren, Thilo$$b6$$eCorresponding author
001028964 773__ $$0PERI:(DE-600)2599550-9$$a10.3233/JPD-240210$$gp. 1 - 6$$n6$$p1271-1276$$tJournal of Parkinson's Disease$$v14$$x1877-7171$$y2024
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