Journal Article

FZJ-2024-04901

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Progressive Supranuclear Palsy: Subcortical Tau Depositions Are Associated with Cortical Perfusion in Frontal and Limbic Regions

Theis, H. ; Barbe, M. T. ; Drzezga, A.FZJ* ; Fink, G. R.FZJ* ; Neumaier, B.FZJ* ; Bischof, G. N.FZJ* ; van Eimeren, T. (Corresponding author)

2024
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.3233/JPD-240210  doi:10.34734/FZJ-2024-04901

Abstract: In progressive supranuclear palsy (PSP), subcortical tau and cortical perfusion can be assessed using the tracer [18F]PI-2620. We investigated if subcortical tau (globus pallidus internus, dentate nucleus) and frontal/limbic perfusion correlate in a cohort of 32 PSP patients. Tau in subcortical regions showed significant negative correlation with perfusion in limbic cortex. Perfusion in frontal regions was negatively associated with tau in both subcortical regions, but the significance threshold was only passed for the dentate nucleus. A reason could be a diaschisis-like phenomenon; that is, subcortical tau could lead to reduced connectivity to frontal regions and, thereby, to decreased perfusion.Keywords: FDG; PET; PSP; [18F]PI-2620; diaschisis; imaging; perfusion; progressive supranuclear palsy; tau.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Molekulare Organisation des Gehirns (INM-2)
3. Nuklearchemie (INM-5)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)
2. DFG project G:(GEPRIS)431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029) (431549029)
3. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)
4. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2024

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