TY  - JOUR
AU  - Theis, Hendrik
AU  - Barbe, Michael T.
AU  - Drzezga, Alexander
AU  - Fink, Gereon R.
AU  - Neumaier, Bernd
AU  - Bischof, Gérard N.
AU  - van Eimeren, Thilo
TI  - Progressive Supranuclear Palsy: Subcortical Tau Depositions Are Associated with Cortical Perfusion in Frontal and Limbic Regions
JO  - Journal of Parkinson's Disease
VL  - 14
IS  - 6
SN  - 1877-7171
CY  - Amsterdam
PB  - IOS Press
M1  - FZJ-2024-04901
SP  - 1271-1276
PY  - 2024
AB  - In progressive supranuclear palsy (PSP), subcortical tau and cortical perfusion can be assessed using the tracer [18F]PI-2620. We investigated if subcortical tau (globus pallidus internus, dentate nucleus) and frontal/limbic perfusion correlate in a cohort of 32 PSP patients. Tau in subcortical regions showed significant negative correlation with perfusion in limbic cortex. Perfusion in frontal regions was negatively associated with tau in both subcortical regions, but the significance threshold was only passed for the dentate nucleus. A reason could be a diaschisis-like phenomenon; that is, subcortical tau could lead to reduced connectivity to frontal regions and, thereby, to decreased perfusion.Keywords: FDG; PET; PSP; [18F]PI-2620; diaschisis; imaging; perfusion; progressive supranuclear palsy; tau.
LB  - PUB:(DE-HGF)16
C6  - 38995804
UR  - <Go to ISI:>//WOS:001320856500018
DO  - DOI:10.3233/JPD-240210
UR  - https://juser.fz-juelich.de/record/1028964
ER  -