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@ARTICLE{Theis:1028964,
      author       = {Theis, Hendrik and Barbe, Michael T. and Drzezga, Alexander
                      and Fink, Gereon R. and Neumaier, Bernd and Bischof, Gérard
                      N. and van Eimeren, Thilo},
      title        = {{P}rogressive {S}upranuclear {P}alsy: {S}ubcortical {T}au
                      {D}epositions {A}re {A}ssociated with {C}ortical {P}erfusion
                      in {F}rontal and {L}imbic {R}egions},
      journal      = {Journal of Parkinson's Disease},
      volume       = {14},
      number       = {6},
      issn         = {1877-7171},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {FZJ-2024-04901},
      pages        = {1271-1276},
      year         = {2024},
      abstract     = {In progressive supranuclear palsy (PSP), subcortical tau
                      and cortical perfusion can be assessed using the tracer
                      [18F]PI-2620. We investigated if subcortical tau (globus
                      pallidus internus, dentate nucleus) and frontal/limbic
                      perfusion correlate in a cohort of 32 PSP patients. Tau in
                      subcortical regions showed significant negative correlation
                      with perfusion in limbic cortex. Perfusion in frontal
                      regions was negatively associated with tau in both
                      subcortical regions, but the significance threshold was only
                      passed for the dentate nucleus. A reason could be a
                      diaschisis-like phenomenon; that is, subcortical tau could
                      lead to reduced connectivity to frontal regions and,
                      thereby, to decreased perfusion.Keywords: FDG; PET; PSP;
                      [18F]PI-2620; diaschisis; imaging; perfusion; progressive
                      supranuclear palsy; tau.},
      cin          = {INM-3 / INM-2 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-2-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project G:(GEPRIS)431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029) / 5252 - Brain
                      Dysfunction and Plasticity (POF4-525) / 5253 - Neuroimaging
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)431549029 /
                      G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38995804},
      UT           = {WOS:001320856500018},
      doi          = {10.3233/JPD-240210},
      url          = {https://juser.fz-juelich.de/record/1028964},
}