TY  - JOUR
AU  - Ray, Debes
AU  - Madani, M.
AU  - Dhont, Jan K. G.
AU  - Platten, Florian
AU  - Kang, Kyongok
TI  - The Effects of Electric Fields on Protein Phase Behavior and Protein Crystallization Kinetics
JO  - The journal of physical chemistry letters
VL  - 15
SN  - 1948-7185
CY  - Washington, DC
PB  - ACS
M1  - FZJ-2024-05143
SP  - 8108 - 8113
PY  - 2024
AB  - We experimentally studied the effects of an externally applied electric field on protein crystallization and liquid–liquid phase separation (LLPS) and its crystallization kinetics. For a surprisingly weak alternating current (AC) electric field, crystallization was found to occur in a wider region of the phase diagram, while nucleation induction times were reduced, and crystal growth rates were enhanced. LLPS on the contrary was suppressed, which diminishes the tendency for a two-step crystallization scenario. The effect of the electric field is ascribed to a change in the protein–protein interaction potential.
LB  - PUB:(DE-HGF)16
C6  - 39087873
UR  - <Go to ISI:>//WOS:001282974800001
DO  - DOI:10.1021/acs.jpclett.4c01744
UR  - https://juser.fz-juelich.de/record/1029468
ER  -