001030418 001__ 1030418
001030418 005__ 20250203133200.0
001030418 0247_ $$2doi$$a10.2967/jnumed.123.265930
001030418 0247_ $$2ISSN$$a0097-9058
001030418 0247_ $$2ISSN$$a0022-3123
001030418 0247_ $$2ISSN$$a0161-5505
001030418 0247_ $$2ISSN$$a1535-5667
001030418 0247_ $$2ISSN$$a2159-662X
001030418 0247_ $$2datacite_doi$$a10.34734/FZJ-2024-05291
001030418 0247_ $$2pmid$$a38575191
001030418 0247_ $$2WOS$$aWOS:001251294600021
001030418 037__ $$aFZJ-2024-05291
001030418 082__ $$a610
001030418 1001_ $$0P:(DE-Juel1)166265$$aBischof, Gérard N.$$b0$$eCorresponding author$$ufzj
001030418 245__ $$aImproved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [18F]PI-2620
001030418 260__ $$aNew York, NY$$bSoc.$$c2024
001030418 3367_ $$2DRIVER$$aarticle
001030418 3367_ $$2DataCite$$aOutput Types/Journal article
001030418 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1738136589_6367
001030418 3367_ $$2BibTeX$$aARTICLE
001030418 3367_ $$2ORCID$$aJOURNAL_ARTICLE
001030418 3367_ $$00$$2EndNote$$aJournal Article
001030418 520__ $$aWe used a new data-driven methodology to identify a set of reference regions that enhanced the quantification of the SUV ratio of the second-generation tau tracer 2-(2-([18F]fluoro)pyridin-4-yl)-9H-pyrrolo[2,3-b:4,5-c′]dipyridine ([18F]PI-2620) in a group of patients clinically diagnosed with 4-repeat tauopathy, specifically progressive supranuclear palsy or cortical basal syndrome. The study found that SUV ratios calculated using the identified reference regions (i.e., fusiform gyrus and crus-cerebellum) were significantly associated with symptom severity and disease duration. This establishes, for the first time to our knowledge, the suitability of [18F]PI-2620 for tracking disease progression in this 4-repeat disease population. This is an important step toward increased clinical utility, such as patient stratification and monitoring in disease-modifying treatment trials. Additionally, the applied methodology successfully optimized reference regions for automated detection of brain imaging tracers. This approach may also hold value for other brain imaging tracers.
001030418 536__ $$0G:(DE-HGF)POF4-5253$$a5253 - Neuroimaging (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001030418 536__ $$0G:(DE-HGF)POF4-5254$$a5254 - Neuroscientific Data Analytics and AI (POF4-525)$$cPOF4-525$$fPOF IV$$x1
001030418 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
001030418 7001_ $$0P:(DE-HGF)0$$aBrendel, Matthias$$b1
001030418 7001_ $$0P:(DE-HGF)0$$aBarthel, Henryk$$b2
001030418 7001_ $$0P:(DE-HGF)0$$aTheis, Hendrik$$b3
001030418 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael$$b4
001030418 7001_ $$0P:(DE-HGF)0$$aBartenstein, Peter$$b5
001030418 7001_ $$0P:(DE-HGF)0$$aClaasen, Joseph$$b6
001030418 7001_ $$0P:(DE-HGF)0$$aDanek, Adrian$$b7
001030418 7001_ $$0P:(DE-HGF)0$$aHöglinger, Günter$$b8
001030418 7001_ $$0P:(DE-HGF)0$$aLevin, Johannes$$b9
001030418 7001_ $$0P:(DE-HGF)0$$aMarek, Ken$$b10
001030418 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b11$$ufzj
001030418 7001_ $$0P:(DE-HGF)0$$aPalleis, Carla$$b12
001030418 7001_ $$0P:(DE-HGF)0$$aPatt, Marianne$$b13
001030418 7001_ $$0P:(DE-HGF)0$$aRullmann, Michael$$b14
001030418 7001_ $$0P:(DE-HGF)0$$aSaur, Dorothee$$b15
001030418 7001_ $$0P:(DE-HGF)0$$aSchroeter, Matthias L.$$b16
001030418 7001_ $$0P:(DE-HGF)0$$aSeibyl, John$$b17
001030418 7001_ $$0P:(DE-HGF)0$$aSong, Mengmeng$$b18
001030418 7001_ $$0P:(DE-HGF)0$$aStephens, Andrew$$b19
001030418 7001_ $$0P:(DE-HGF)0$$aSabri, Osama$$b20
001030418 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b21$$ufzj
001030418 7001_ $$0P:(DE-Juel1)169110$$avan Eimeren, Thilo$$b22
001030418 773__ $$0PERI:(DE-600)2040222-3$$a10.2967/jnumed.123.265930$$gVol. 65, no. 6, p. 952 - 955$$n6$$p952 - 955$$tJournal of nuclear medicine$$v65$$x0097-9058$$y2024
001030418 8564_ $$uhttps://juser.fz-juelich.de/record/1030418/files/Improved%20Tau%20PET%20SUVR%20Quantification%20in%204-Repeat%20Tau%20Phenotypes%20with%20%5B18F%5DPI-2620.pdf$$yOpenAccess$$zStatID:(DE-HGF)0510
001030418 909CO $$ooai:juser.fz-juelich.de:1030418$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
001030418 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)166265$$aForschungszentrum Jülich$$b0$$kFZJ
001030418 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)166419$$aForschungszentrum Jülich$$b11$$kFZJ
001030418 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)177611$$aForschungszentrum Jülich$$b21$$kFZJ
001030418 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5253$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001030418 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5254$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x1
001030418 9141_ $$y2024
001030418 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-24
001030418 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-10-24
001030418 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-24
001030418 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
001030418 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ NUCL MED : 2022$$d2025-01-01
001030418 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-01-01
001030418 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-01-01
001030418 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-01-01
001030418 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2025-01-01
001030418 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2025-01-01
001030418 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2025-01-01
001030418 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-01-01
001030418 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bJ NUCL MED : 2022$$d2025-01-01
001030418 920__ $$lyes
001030418 9201_ $$0I:(DE-Juel1)INM-5-20090406$$kINM-5$$lNuklearchemie$$x0
001030418 9201_ $$0I:(DE-Juel1)INM-2-20090406$$kINM-2$$lMolekulare Organisation des Gehirns$$x1
001030418 980__ $$ajournal
001030418 980__ $$aVDB
001030418 980__ $$aI:(DE-Juel1)INM-5-20090406
001030418 980__ $$aI:(DE-Juel1)INM-2-20090406
001030418 980__ $$aUNRESTRICTED
001030418 9801_ $$aFullTexts