Journal Article

FZJ-2024-05291

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [18F]PI-2620

Bischof, G. N. (Corresponding author)FZJ* ; Brendel, M. ; Barthel, H. ; Theis, H. ; Barbe, M. ; Bartenstein, P. ; Claasen, J. ; Danek, A. ; Höglinger, G. ; Levin, J. ; Marek, K. ; Neumaier, B.FZJ* ; Palleis, C. ; Patt, M. ; Rullmann, M. ; Saur, D. ; Schroeter, M. L. ; Seibyl, J. ; Song, M. ; Stephens, A. ; Sabri, O. ; Drzezga, A.FZJ* ; van Eimeren, T.

2024
Soc. New York, NY

This record in other databases:      

Please use a persistent id in citations: doi:10.2967/jnumed.123.265930  doi:10.34734/FZJ-2024-05291

Abstract: We used a new data-driven methodology to identify a set of reference regions that enhanced the quantification of the SUV ratio of the second-generation tau tracer 2-(2-([18F]fluoro)pyridin-4-yl)-9H-pyrrolo[2,3-b:4,5-c′]dipyridine ([18F]PI-2620) in a group of patients clinically diagnosed with 4-repeat tauopathy, specifically progressive supranuclear palsy or cortical basal syndrome. The study found that SUV ratios calculated using the identified reference regions (i.e., fusiform gyrus and crus-cerebellum) were significantly associated with symptom severity and disease duration. This establishes, for the first time to our knowledge, the suitability of [18F]PI-2620 for tracking disease progression in this 4-repeat disease population. This is an important step toward increased clinical utility, such as patient stratification and monitoring in disease-modifying treatment trials. Additionally, the applied methodology successfully optimized reference regions for automated detection of brain imaging tracers. This approach may also hold value for other brain imaging tracers.

---

Contributing Institute(s):

1. Nuklearchemie (INM-5)
2. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)
2. 5254 - Neuroscientific Data Analytics and AI (POF4-525) (POF4-525)

Appears in the scientific report 2024

---

Database coverage:
; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---